An Oncogene-Induced DNA Damage Model for Cancer Development
Explore this paper's citation graph
Summary
Oncogene-induced DNA damage may explain two key features of cancer: genomic instability and the high frequency of p53 mutations.
- Type
- review
- Published
- 2008-03-07
- Cited by
- 1,901
- References
- 144
- OpenAlex
- https://openalex.org/W2086333179
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16426080
Keywords
Genome instability, DNA damage, Biology, DNA, Oncogene
References
- Multiple Pathways Leading to Genomic Instabiligy and Tumorigenesis
- Genomic instability in MycER-activated Rat1A-MycER cells
- Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.
- The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19ARF
- The Consensus Coding Sequences of Human Breast and Colorectal Cancers
- IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW,Thompson RW,et al//Proc Natl Acad Sci U S A
- Loss of atm radiosensitizes multiple p53 null tissues.
- Proliferation, cell cycle and apoptosis in cancer
- Mutator phenotype may be required for multistage carcinogenesis.
- Genetic instabilities in human cancers
- Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
- Repair deficient human disorders and cancer
- Cell-cycle checkpoints and cancer
- The role of chromosomal instability in tumor initiation
- Cyclin D-dependent kinases, INK4 inhibitors and cancer.
- Telomere dysfunction provokes regional amplification and deletion in cancer genomes.
- The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
- A DNA damage checkpoint response in telomere-initiated senescence
- DNA damage foci at dysfunctional telomeres.
- Suppressing Cancer: The Importance of Being Senescent
Cited by
- Differential Toxicity of DNA Adducts of Mitomycin C
- An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
- Targeting the cell cycle in esophageal adenocarcinoma: an adjunct to anticancer treatment.
- Interconnected contribution of tissue morphogenesis and the nuclear protein NuMA to the DNA damage response
- DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis in human embryo lung fibroblast cells.
- The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability
- Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin
- The DNA damage checkpoint response to replication stress: A Game of Forks
- Regulation of Rad17 Protein Turnover Unveils an Impact of Rad17-APC Cascade in Breast Carcinogenesis and Treatment*
- Dissecting the telomere-independent pathways underlying human cellular senescence
- Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells
- Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy
- Translocations in normal B cells and cancers: insights from new technical approaches.
- Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis
- ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer
- A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression
- SAMHD1 and the innate immune response to cytosolic DNA during DNA replication.
- Comparative Analysis of the Formation of γH2AX Foci in Human Mesenchymal Stem Cells Exposed to 3H-Thymidine, Tritium Oxide, and X-Rays Irradiation
- Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
- The role of the Common Fragile Site Gene product, Fhit, in protection from DNA Damage
Related papers
- Molecular chaperones in DNA repair mechanisms: Role in genomic instability and proteostasis in cancer.
- Aberrations in DNA repair pathways in cancer and therapeutic significances.
- DNA repair defects and implications for immunotherapy.
- Impact of G-Quadruplexes on the Regulation of Genome Integrity, DNA Damage and Repair
- Suppression of gross chromosomal rearrangements by a new alternative replication factor C complex.
- Initiation of DNA Interstrand Cross-link Repair in Mammalian Cells