Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin
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Summary
In normal cells, serum starvation in vitro induces a cell cycle arrest and protects from CDDP induced toxicity, and proliferation of cancer cells is only moderately reduced by serum starvation whereas CDDP toxicity is enhanced.
- Type
- article
- Published
- 2012-12-01
- Cited by
- 119
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W23211021
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16082971
Keywords
Political science, Humanities, Art
References
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- Effects of short‐term food deprivation on orexin‐A‐induced intestinal bicarbonate secretion in comparison with related secretagogues
- A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
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- Pemetrexed in advanced non-small-cell lung cancer
- Variations in Mre11/Rad50/Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel
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- Involvement of AMP-activated Protein Kinase (AMPK) in Regulation of Cell Membrane Potential in a Gastric Cancer Cell Line
- Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors
- PKC-δ/PKC-α activity balance regulates the lethal effects of cisplatin.
- Blood DNA methylation biomarkers for breast cancer risk
- Dietary Restriction and Nutrient Balance in Aging
- Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition
- Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- Dysregulated metabolism contributes to oncogenesis
- AMP-activated protein kinase (AMPK) beyond metabolism
- Mesenchymal-endothelial-transition contributes to cardiac neovascularization
- Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer
- Comparison of Intracellular Stress Response of NCI-H526 Small Cell Lung Cancer (SCLC) Cells to Platinum(II) Cisplatin and Platinum(IV) Oxoplatin
- Hedgehog signaling is synergistically enhanced by nutritional deprivation and ligand stimulation in human fibroblasts of Gorlin syndrome.
- Co-inhibition of epidermal growth factor receptor and insulin-like growth factor receptor 1 enhances radiosensitivity in human breast cancer cells
- Neural stem and progenitor cell fate transition requires regulation of Musashi1 function
- Serum starvation regulates E-cadherin upregulation via activation of c-Src in non-small-cell lung cancer A549 cells.
- IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma
- Fasting: Molecular Mechanisms and Clinical Applications
- Role of c-Kit in the growth, migration and differentiation of human cardiac progenitor cells.
- Autophagy in blood cancers: biological role and therapeutic implications
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