An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Keywords

Apoptosis, Cancer research, In vivo, Programmed cell death, Small molecule

References

• Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3Maria Pumborios — 2001
• Oblimersen Bcl-2 Antisense: Facilitating Apoptosis in Anticancer TreatmentRichard Klasa, Amanda M. Gillum, Robert E. Klem — 2002
• Discovering High-Affinity Ligands for Proteins: SAR by NMRSuzanne B. Shuker, Philip J. Hajduk, Robert Meadows — 1996
• Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.Anthony Letai, Michael C. Bassik, Loren D. Walensky — 2002
• Promise and problems of Bcl-2 antisense therapy.John C. Reed — 1997
• Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs.Jonathan B. Baell, David C.S. Huang — 2002
• Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and DeathMichael C. Wei, Wei‐Xing Zong, Emily H. Cheng — 2001
• Development of a high-throughput fluorescence polarization assay for Bcl-x(L).Haichao Zhang, Paul Nimmer, Saul H. Rosenberg — 2002
• Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 HelixLoren D. Walensky, Andrew L. Kung, Iris Escher — 2004
• Rational design of diflunisal analogues with reduced affinity for human serum albumin.Hongyuan Mao, Philip J. Hajduk, R.G. Craig — 2001
• Expression, refolding, and isotopic labeling of human serum albumin domains for NMR spectroscopy.Hongyuan Mao, Angelo Gunasekera, Stephen W. Fesik — 2000
• The role of Bcl-2 family members in tumorigenesis.Vladimir Kirkin, Stefan Joos, Martin Zörnig — 2004
• An exact mathematical expression for describing competitive binding of two different ligands to a protein moleculeZhixin Wang — 1995
• Antiapoptotic BCL-2 is required for maintenance of a model leukemia.Anthony Letai, Mia D. Sorcinelli, Caroline Beard — 2004
• Bcl-2-family proteins: the role of the BH3 domain in apoptosis.Ameeta Kelekar, Craig B. Thompson — 1998
• Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.Shinichi Kitada, Marilisa Leone, Sina Sareth — 2003
• Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation.Yoshihide Tsujimoto, L R Finger, Jorge J. Yunis — 1984
• Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of ApoptosisMichael Sattler, Heng Liang, David G. Nettesheim — 1997
• Structural biology of the Bcl-2 family of proteins.Andrew M. Petros, Edward T. Olejniczak, Stephen W. Fesik — 2004
• Solution structure of the antiapoptotic protein bcl-2Andrew M. Petros, A Medek, David G. Nettesheim — 2001

Cited by

• La protéine de stress Hsp27 / HspB1, une cible de choix en thérapie anti-cancéreuseBenjamin Gibert — 2010
• Mast cell apoptosis and survival.Maria Ekoff, Gunnar Nilsson — 2011
• Apoptoseresistenz in malignen TumorenWilfried Roth — 2009
• Crosstalk Between Apoptosis and Autophagy : BH3 Mimetics Activate Multiple Pro-Autophagic PathwaysShoaib Ahmad Malik — 2012
• Drug Resistance Mechanisms to Gamma-secretase Inhibitors in Human Colon Cancer CellsCindy R. Timme — 2013
• Noncanonical functions of BCL-2 proteins in the nervous system.Heather M. Lamb, J. Marie Hardwick — 2010
• Big wheel keeps on turning: apoptosome regulation and its role in chemoresistanceKok Ming Ng — 2008
• The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology.Alexander Haggerty Krappe — 2008
• Overcoming resistance to apoptosis in cancer therapy.Patrick Albert — 2008
• Oxidative Stress by Targeted Agents Promotes Cytotoxicity in Hematologic MalignanciesPaulo Matos, Larissa Kotelevets, Vânia Gonçalves — 2009
• The role of apoptosis in radiation oncologyMark F. J. Steel, Jacek Osiewalski — 2009
• The antiapoptotic protein AAC‐11 interacts with and regulates Acinus‐mediated DNA fragmentationRafael Escobar — 2009
• BH3‐only proteins: The death‐puppeteer's wiresStephen Blackmore, D. F. Cutler — 2009
• Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survivalЗахаров Василий Иванович — 2010
• Proline-rich sequence recognition domains (PRD): ligands, function and inhibition.Christian Freund, Hans‐Günther Schmalz, Jana Sticht — 2008
• NMR studies of protein-ligand interactions.Michael Goldflam, Teresa Tarragó, Margarida Gairí — 2012
• Targeting apoptosis pathways in lung cancer.Eko Susektyo Kuspradiyanto — 2013
• microRNA-21 promotes cardiac fibrosis and development of heart failure with preserved left ventricular ejection fraction by up-regulating Bcl-2.Shuguang Dong, Wenhan Ma, Bohan Hao — 2014
• Platinum resistant cancer cells conserve sensitivity to BH3 domains and obatoclax induced mitochondrial apoptosisPatricia A. Gutiérrez — 2011
• Intrinsic Resistance to Chemotherapy in Breast Cancer純 佐々木, 文夫 田中, 雅之 大道 — 2010

Related papers

• Cytotoxicity test of medical device with silver nanoparticlesXI Ting-fei — 2010
• Synthesis and antitumor activity of aza-chalcones and their Pt(IV) complexesShuxiang Wang, Wenqing Shao, Jie Duan — 2011
• Protective effect of Cynomorii Herba extract on H_2O_2-induced cytotoxicityMyung‐Sook Oh, Do-Rim Kim, Woong-Mo Yang — 2004
• Amyloid β cytotoxicity is enhanced or reduced depending on formation of amyloid β oligomeric formsMd. Shahnawaz, Tahmina Bilkis, Il‐Seon Park — 2020
• An In Vitro Investigation of Pulmonary Alveolar Macrophage Cytotoxicity Introduced by Fibrous and Grainy Mineral DustsDong, Faqin, Deng — 2006
• Study of Whakijogyung-Tang about cytotoxicity in S-180Dae-Su Kim, Jeong-Hwa Choi, Jonghan Kim — 2007
• Enhanced human monocyte cytotoxicity by platelet-activating factor.Frank H. Valone, Ramila Philip, Robert J. Debs — 1988
• Factors affecting stimulation of natural cytotoxicity to a rat lymphoma by Corynebacterium parvum.James Flexman, G. R. Shellam — 1980