Rational design of diflunisal analogues with reduced affinity for human serum albumin.
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Summary
The results suggest a rational strategy for designing out albumin binding in potential drug molecules by using structure-based design in conjunction with NMR-based screening, and several of these compounds maintain activity against cyclooxygenase-2.
- Type
- article
- Published
- 2001-10-09
- Cited by
- 89
- References
- 0
- OpenAlex
- https://openalex.org/W2011472036
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6617801
Keywords
Diflunisal, Chemistry, Human serum albumin, Albumin, Serum albumin
References
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