Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.
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Summary
The deliberate creation of novel site-specific endonucleases by linking two different zinc finger proteins to the cleavage domain of Fok I endonuclease and the zinc finger motifs opens the way to generate many new enzymes with tailor-made sequence specificities desirable for various applications.
- Type
- article
- Published
- 1996-02-06
- Cited by
- 1,990
- References
- 24
- Access
- Open access
- OpenAlex
- https://openalex.org/W2078308455
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23988918
Keywords
Restriction enzyme, Zinc finger, Recognition sequence, Zinc finger nuclease, Nuclease
References
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- The fokI restriction-modification system. I. Organization and nucleotide sequences of the restriction and modification genes.
- Use of T7 RNA polymerase to direct expression of cloned genes.
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- Building zinc fingers by selection: toward a therapeutic application.
- Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.
- Zinc finger phage: affinity selection of fingers with new DNA-binding specificities.
- The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition
- Class-IIS restriction enzymes--a review.
- Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions.
- Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins.
- Toward a code for the interactions of zinc fingers with DNA: Selection of randomized fingers displayed on phage
- New metal chelate adsorbent selective for proteins and peptides containing neighbouring histidine residues.
- Chimeric restriction endonuclease.
- Alteration of the cleavage distance of Fok I restriction endonuclease by insertion mutagenesis.
- In vitro selection of zinc fingers with altered DNA-binding specificity.
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
- Length-encoded multiplex binding site determination: application to zinc finger proteins.
- Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins.
Cited by
- DNA hydrolysis and genome editing applications of GIY-YIG family homing endonucleases
- Developing biocontainment strategies to suppress transgene escape via pollen dispersal from transgenic plants
- Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases.
- Development of nuclease-mediated site-specific genome modification.
- TALENs: a widely applicable technology for targeted genome editing
- Targeted meiotic recombination in Arabidopsis thaliana
- DNA Replicons for Plant Genome Engineering[W][OPEN]
- Molecular scissors and their application in genetically modified farm animals
- Diseño y desarrollo funcional de modelos vectoriales derivados de lentivirus deficientes en integración para la modificación génica específica de sitio
- CRISPR-Cas Genome Surgery in Ophthalmology
- Zinc-finger nucleases-based genome engineering to generate isogenic human cell lines.
- CRISPR/Cas9 Technology: Applications and Human Disease Modeling.
- Ways of improving precise knock-in by genome-editing technologies
- Inactivation of hepatitis B virus CCCDNA using engineered transcription activator-like affector nucleases
- Designing zinc finger nucleases that specifically cleave Hepatitis B viral DNA
- AAV vectors for gene correction.
- Lentiviral gene therapy for HIV using TRIM-cyclophilin restriction factors
- Improving lentiviral vector-mediated gene transfer by understanding cellular barriers
- Using nucleases to stimulate homologous recombination.
- Engineered zinc finger proteins for manipulation of the human mitochondrial genome.
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