Ways of improving precise knock-in by genome-editing technologies
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Summary
The main part of the review is devoted to the ways of increasing precise and effective knock-in: inhibition of non-homologous end joining and stimulation of homology-directed repair key factors, use of small molecules with unknown mechanism of action, cell-cycle synchronization and cell- cycle-dependent activity of Cas9, donor molecule design, selection, alternative methods for insertion and other approaches.
- Type
- article
- Published
- 2018-11-02
- Cited by
- 29
- References
- 148
- OpenAlex
- https://openalex.org/W30390160
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:53254808
Keywords
Bradykinin, Captopril, Fosinopril, Angiotensin-converting enzyme, Enalaprilat
References
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- Genetic engineering of human ES and iPS cells using TALE nucleases
- Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases
- Improved Gene Targeting through Cell Cycle Synchronization
- Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated From Patient iPSCs
- Repair Pathway Choices and Consequences at the Double-Strand Break
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- piggyBac-ing models and new therapeutic strategies
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- Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila
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- Rad51 Protein Controls Rad52-mediated DNA Annealing*
- Genome engineering using the CRISPR-Cas9 system
Cited by
- SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses
- CRISPR/Cas12a-assisted PCR tagging of mammalian genes
- Solution NMR backbone assignment reveals interaction-free tumbling of human lineage-specific Olduvai protein domains
- LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases
- Human Induced Pluripotent Stem-Cell-Derived Cardiomyocytes as Models for Genetic Cardiomyopathies
- TIRR: a potential front runner in HDR race−hypotheses and perspectives
- CRISPR-Cas12a–assisted PCR tagging of mammalian genes
- Allele-specific endogenous tagging and quantitative analysis of β-catenin in colon cancer cells
- A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing
- Gene Editing for Treatment and Prevention of Human Diseases: A Global Survey of Gene Editing-Related Researchers
- One-step genotyping method in CRISPR based on short inner primer-assisted, tetra primer-paired amplifications.
- CRISPR/Cas9-mediated genome editing in Hevea brasiliensis
- Electroporation-Mediated Genome Editing of Livestock Zygotes
- CRISPR-Cas9 Delivery with the Ribonucleoprotein Complexes Increased EGFP Editing Efficiency
- Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells
- Principles and Applications of CRISPR Toolkit in Virus Manipulation, Diagnosis, and Virus-Host Interactions
- Improving Homology-Directed Repair in Genome Editing Experiments by Influencing the Cell Cycle
- CRISPR/Cas9 (D10A) nickase-mediated Hb CS gene editing and genetically modified fibroblast identification
- Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cells
- The Choice of a Donor Molecule in Genome Editing Experiments in Animal Cells
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