Fcγ receptors as regulators of immune responses
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Summary
Recent studies addressing the multifaceted roles of FcRs for IgG (FcγRs) in the immune system are discussed and how this knowledge could be translated into novel therapeutic strategies to treat human autoimmune, infectious or malignant diseases are discussed.
- Type
- review
- Published
- 2008-01-01
- Cited by
- 2,656
- References
- 136
- OpenAlex
- https://openalex.org/W2075901113
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34597359
Keywords
Immune system, Receptor, Immunology, Antibody, Biology
References
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- High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR*
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- The 3.2-Å crystal structure of the human IgG1 Fc fragment–FcγRIII complex
- FcR-Bearing Myeloid Cells Are Responsible for Triggering Murine Lupus Nephritis1
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Cited by
- Analysis of antibody neutralization specificities in human immunodeficiency virus type 2 infection
- A Novel Activating Chicken IgY FcR Is Related to Leukocyte Receptor Complex (LRC) Genes but Is Located on a Chromosomal Region Distinct from the LRC and FcR Gene Clusters1
- Distinct kinetics and dynamics of cross‐presentation in liver sinusoidal endothelial cells compared to dendritic cells
- Polyclonal immunoglobulins (IVIg) induce expression of MMP-9 in microglia.
- Differential Recruitment of Activating and Inhibitory FcγRII during Phagocytosis
- Monocyte and Macrophage Abnormalities in Systemic Lupus Erythematosus
- C‐reactive protein‐derived peptide 201–206 inhibits neutrophil adhesion to endothelial cells and platelets through CD32
- Intravenous immunoglobulins modulate neutrophil activation and vascular injury through FcγRIII and SHP-1
- Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-life
- Immunoglobulin G Fc receptor deficiency prevents Alzheimer-like pathology and cognitive impairment in mice.
- Isotype-switched immunoglobulin G antibodies to HIV Gag proteins may provide alternative or additional immune responses to ‘protective’ human leukocyte antigen-B alleles in HIV controllers
- Antibody-Dependent, FcγRI-Mediated Neutralization of HIV-1 in TZM-bl Cells Occurs Independently of Phagocytosis
- Functional Education of Invariant NKT Cells by Dendritic Cell Tuning of SHP-1
- B cell-regulated immune responses in tumor models and cancer patients
- Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles
- The expression of Fcγ receptors in Hashimoto's thyroiditis.
- Up-regulation of CD64-expressing monocytes with impaired FcγR function reflects disease activity in polyarticular psoriatic arthritis
- FCGR3A-V158F polymorphism is a disease-specific pharmacogenetic marker for the treatment of psoriasis with Fc-containing TNFα inhibitors
- Dietary flavonoids and modulation of natural killer cells: implications in malignant and viral diseases.
- Microglia are continuously activated in the circumventricular organs of mouse brain.
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