Antibodies Given Orally in the Neonatal Period Can Affect the Immune Response for Two Generations: Evidence for Active Maternal Influence on the Newborn's Immune System
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Summary
The results demonstrate that by giving monoclonal antibodies idiotypically connected to a single bacterial component to neonatal rats, one profoundly influence the immune response also to other—spatially related—bacterial antigens in their offsprings.
- Type
- article
- Published
- 1999-12-01
- Cited by
- 41
- References
- 29
- OpenAlex
- https://openalex.org/W1972479046
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30504039
Keywords
Immune system, Antigen, Ovalbumin, Antibody, Biology
References
- Induction of TH1 and TH2 Immunity in Neonatal Mice
- The immunological response of the rat to infection with taeniaeformis. IV. Immunoglobulins involved in passive transfer of resistance from mother to offspring.
- Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile.
- Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice.
- Antibody-forming cells in human colostrum after oral immunisation
- Expansion of memory Th2 cells over Th1 cells in neonatal primed mice.
- Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the expansion of idiotype-specific helper T cells
- Idiotypic Regulation of Development of the B‐Cell Repertoire
- Idiotypic regulation by isologous monoclonal anti-idiotope antibodies
- Establishment of idiotypic helper T-cell repertoires early in life
- Neonatal Tolerance Induced by Antibody against Antigen-Specific Receptor
- Antibody response of mice following neonatal treatment with a monoclonal anti‐receptor antibody. Evidence for B cell tolerance and T suppressor cells specific for different idiotopic determinants
- Neonatal colonization of rats induces immunological tolerance to bacterial antigens
- A functional idiotypic network of T helper cells and antibodies, limited to the compartment of “naturally” activated lymphocytes in normal mice
- Large-scale production of monoclonal antibodies in dialysis tubing.
- Postnatal Changes in mucosal immune response: A physiological perspective of breast feeding and weaning
- Oral Tolerization Leads to Active Suppression and Bystander Tolerance in Adult Rats while Anergy Dominates in Young Rats
- Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity
- Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells
- Expression of new idiotypes following neonatal idiotypic suppression of a dominant clone
Cited by
- The influence of environment on development of the mucosal immune system.
- Maturation of immunocompetence in breast-fed vs. formula-fed infants.
- An Established Immune Response against Ovalbumin is Suppressed by a Transferable Serum Factor Produced after Ovalbumin Feeding: A Role of CD25+ Regulatory Cells
- Inibição da resposta de hipersensibilidade do Tipo I da prole de camundongos mediada pela imunização materna com o ácaro Dermatophagoides Pteronyssinus* Inhibition of offspring Type I hypersensitivity response through maternal immunization with the dust mite Dermatophagoides Pteronyssinus*
- Die Auswirkung der Reproduktion auf das Immunsystem weiblicher Hausmeerschweinchen (Cavia porcellus)
- Health and immune responses in a rat model after intake of organically or conventionally grown foods
- Short- and long-term consequences of food resources on Ural owl Strix uralensis reproduction
- Maternal antibodies in a wild altricial bird: effects on offspring immunity, growth and survival.
- Immune system modulation by human milk.
- Comparison between conventional and organic agriculture in terms of nutritional quality of food - a critical review
- Preconception maternal immunization to dust mite inhibits the type I hypersensitivity response of offspring.
- Maternal antibodies reduce costs of an immune response during development
- Genetic variations in maternal transfer and immune responsiveness to infectious bursal disease virus.
- The Transfer of Immunity from Mother to Child
- Immune function across generations: integrating mechanism and evolutionary process in maternal antibody transmission
- The mother‐offspring dyad and the immune system
- Prehatching maternal investment and offspring immunity in the pied flycatcher (Ficedula hypoleuca)
- Mendelian and transgenerational inheritance in hypertensive renal disease
- Influence of Maternal Murine Immunization with Dermatophagoides pteronyssinus Extract on the Type I Hypersensitivity Response in Offspring
- Dynamics of anti-Borrelia antibodies in Black-legged Kittiwake (Rissa tridactyla) chicks suggest a maternal educational effect
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