Distinct kinetics and dynamics of cross‐presentation in liver sinusoidal endothelial cells compared to dendritic cells
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Summary
The results provide a mechanistic explanation how organ‐resident LSECs accommodate continuous scavenger function with the capacity to cross‐present circulating antigens using distinct kinetics and dynamics of antigen‐uptake, routing and cross‐ presentation compared to DCs.
- Type
- article
- Published
- 2009-09-01
- Cited by
- 96
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W19610048
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12060427
Keywords
Field (mathematics), Layer (electronics), Materials science, Mathematics, Composite material
References
- A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection
- Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance
- Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8− Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells1
- Constitutive class I-restricted exogenous presentation of self antigens in vivo
- Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7‐homolog 1‐dependent CD8+ T cell tolerance
- ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells
- Priming of T cells by exogenous antigen cross-presented on MHC class I molecules.
- Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
- Activation and inhibition of lymphocytes by costimulation.
- Endothelial cell–mediated uptake of a hepatitis B virus: A new concept of liver targeting of hepatotropic microorganisms
- Local control of the immune response in the liver
- Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1
- Mouse and human dendritic cell subtypes
- Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo
- L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus
- Systemic antigen cross‐presented by liver sinusoidal endothelial cells induces liver‐specific CD8 T‐cell retention and tolerization
- Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study
- Cellular mechanisms governing cross-presentation of exogenous antigens
- Long‐lasting cross‐presentation of tumor antigen in human DC
- Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation
Cited by
- Mechanisms Balancing Tolerance and Immunity in the Liver
- Updated management of hepatocellular carcinoma
- Specific gene delivery to liver sinusoidal and artery endothelial cells.
- Outcome of patients suffering from a spontaneous reactivation of hepatitis B presenting as acute‐on‐chronic liver failure and treated with antivirals
- Vitamin D deficiency may link diabetes and liver neoplasms
- Virological breakthrough and resistance in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice
- Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice.
- The role of hepatic immune regulation in systemic immunity to viral infection
- TGF-β-dependent induction of CD4⁺CD25⁺Foxp3⁺ Tregs by liver sinusoidal endothelial cells.
- Carnitine palmitoyltransferase as a potential target for treating diabetes: Is inhibition or activation preferable?
- Association of the cannabinoid receptor 2 (CB2) Gln63Arg polymorphism with indices of liver damage in obese children: An alternative way to highlight the CB2 hepatoprotective properties
- Hepatic immune regulation by stromal cells.
- Lack of an association between an apolipoprotein C3 genetic variant and the liver fat content in patients with type 2 diabetes
- Cellular and Molecular Targeting for Nanotherapeutics in Transplantation Tolerance
- Liver Antigen-Presenting Cells
- Antigen-presenting cell function in the tolerogenic liver environment
- Hepatic immune regulation and its involvement in viral hepatitis infection.
- Stem cells or macrophages: Which contribute to bone marrow cell therapy for liver cirrhosis?
- Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity.
- Human hepatic stellate cells are liver‐resident antigen‐presenting cells
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