The 3.2-Å crystal structure of the human IgG1 Fc fragment–FcγRIII complex
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Summary
The described structure of a soluble Fcγ receptor (sFcγRIII, CD16), an Fc fragment from human IgG1 (hFc1) and their complex is a model for immune complex recognition and helps to explain the vastly differing affinities of other F cγR–IgG complexes and the FcεRIα-IgE complex.
- Type
- article
- Published
- 2000-07-20
- Cited by
- 686
- References
- 49
- OpenAlex
- https://openalex.org/W1825768998
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4306592
Keywords
Immunoglobulin Fc Fragments, Fragment crystallizable region, Fc receptor, Receptor, Opsonin
References
- Clinical experience with CD64-directed immunotherapy. An overview
- Polymorphism in mitogenic effect of IgG1 monoclonal antibodies against T3 antigen on human T cells
- Site of binding of IgG2b and IgG2a by mouse macrophage Fc receptors by using cyanogen bromide fragments.
- Crystal structure of the human leukocyte Fc receptor, FcγRIIa.
- Cell type-specific glycoforms of Fc gamma RIIIa (CD16): differential ligand binding.
- A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding.
- Triggering of histamine release from rat mast cells by divalent antibodies against IgE-receptors.
- Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc domain of human IgG.
- The IgG Fc receptor family
- Crystal structure of the human high-affinity IgE receptor.
- Localization of the binding site for the human high-affinity Fc receptor on IgG
- Multiple Regions of Human FcγRII (CD32) Contribute to the Binding of IgG (*)
- Crystallography & NMR system: A new software suite for macromolecular structure determination.
- The second and third extracellular domains of FcgammaRI (CD64) confer the unique high affinity binding of IgG2a.
- Thermodynamics of the interaction of human immunoglobulin E with its high-affinity receptor Fc epsilon RI.
- The CCP4 suite: programs for protein crystallography.
- Superconducting Single Crystals of Tl2Ba2CaCu2O8 and YBa2Cu4O8: Crystal Structures in the Vicinity of Tc
- A program to produce both detailed and schematic plots of protein structures
- Fine Structure Analysis of Interaction of FcεRI with IgE*
- Human Fc gamma Receptor IIb Expressed in Escherichia coli Reveals IgG Binding Capability
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- Generation of Rituximab Polymer May Cause Hyper-Cross-linking–Induced Apoptosis in Non-Hodgkin's Lymphomas
- Efficient expression of recombinant soluble human FcγRI in mammalian cells and its characterization.
- Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains
- Interactions of immunoglobulins outside the antigen-combining site.
- Fc receptor homologs (FcRH1-5) extend the Fc receptor family.
- Structural insights into antibody-mediated mucosal immunity.
- Interactions between complement and cellular mediated mechanisms of monoclonal antibody therapy
- Genome-Wide Association Studies: Progress in Identifying Genetic Biomarkers in Common, Complex Diseases
- Using LongSAGE to Detect Biomarkers of Cervical Cancer Potentially Amenable to Optical Contrast Agent Labelling
- Fcα/μR: single member or first born in the family?
- Engineered antibody for treating lymphoma.
- The FcγR of humans and non-human primates and their interaction with IgG: implications for induction of inflammation, resistance to infection and the use of therapeutic monoclonal antibodies.
- Glycosylation of natural and recombinant antibody molecules.
- Analysis and Manipulation of Recombinant Glycoproteins Manufactured in Mammalian Cell Culture
- Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design.
- Polimorfismos del receptor Fc gamma en patología cutánea inmunomediada: Papel en la patogenia del penfigoide ampolloso y en la respuesta a tratamiento biológico en la psoriasis
- Structural biology of IgG Fc glycoforms
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