P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo.
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Summary
The results suggest that P-gp/MDR1 overexpression is related to acquired multidrug resistance in lung cancer in vivo.
- Type
- article
- Published
- 1996-12-01
- Cited by
- 2,453
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W2074854901
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26672542
Keywords
In vivo, P-glycoprotein, Multiple drug resistance, Lung cancer, Doxorubicin
References
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- In vivo acquired drug resistance and multidrug resistance gene (MDR1) expression in the KB carcinoma cell line xenotransplanted in nude mice.
- New immunohistochemical "sandwich" staining method for mdr1 P-glycoprotein detection with JSB-1 monoclonal antibody in formalin-fixed, paraffin-embedded human tissues.
- Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.
- Lung cancer : a comprehensive treatise
- Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.
- Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression.
- Multidrug-resistance gene (mdr1) expression in human tumor xenografts.
- Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.
- Pharmacokinetic Approach to Rational Therapeutic Doses for Human Tumor‐bearing Nude Mice
- Expression of Multidrug Resistance Gene in Human Cancers
- Expression of a multidrug-resistance gene in human tumors and tissues.
- Isolation and expression of a complementary DNA that confers multidrug resistance
- Overexpression of P-glycoprotein and glutathione S-transferase-pi in resistant non-small cell lung carcinomas of smokers.
- Evaluation of antitumor activity in a human breast tumor/nude mouse model with a special emphasis on treatment dose
- Expression of the multidrug resistance-associated protein (MRP) gene in non-small-cell lung cancer.
- Sequential coexpression of the multidrug resistance genes MRP and mdr1 and their products in VP-16 (etoposide)-selected H69 small cell lung cancer cells.
- HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II.
- Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs.
- In vivo selection of human tumor cells resistant to monoclonal antibody-Vinca alkaloid immunoconjugates.
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- Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.
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- A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer
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