Isolation and expression of a complementary DNA that confers multidrug resistance
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Summary
The isolation of DNA clones complementary to the cellular messenger RNA transcripts of mdr genes are reported and it is shown that high-level expression of a full-length complementary DNA clone in an otherwise drug-sensitive cell confers a complete multidrug-resistant phenotype.
- Type
- article
- Published
- 1986-10-23
- Cited by
- 765
- References
- 21
- OpenAlex
- https://openalex.org/W2049683781
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4352729
Keywords
Multiple drug resistance, Biology, Gene, Drug resistance, Complementary DNA
References
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- Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins.
- Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells
- Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.
- Screening lambdagt recombinant clones by hybridization to single plaques in situ.
- Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines.
- Characterization of cell lines showing growth control isolated from both the wild type and a leucyl‐tRNA synthetase mutant of chinese hamster ovary cells
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
- Reduced permeability in CHO cells as a mechanism of resistance to colchicine
- Detection and mapping of homologous, repeated and amplified DNA sequences by DNA renaturation in agarose gels.
- Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis.
- Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.
- DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.
- A simple and very efficient method for generating cDNA libraries.
- The construction of cosmid libraries which can be used to transform eukaryotic cells.
Cited by
- Morphologic alterations in drug sensitive vs. drug resistant cells due to cytostatic application.
- Importance of theHpaI-P sequence for herpes simplex virus-1 replication in the adrenal glands
- Daunorubicin and vincristine binding to plasma membrane vesicles from daunorubicin-resistant and wild type Ehrlich ascites tumor cells.
- Resistance of multidrug‐resistant lines to natural killer‐like cell‐mediated cytotoxicity
- P-glycoprotein homologues.
- A homologue of the mammalian multidrug resistance gene (mdr) is functionally expressed in the intestine of Xenopus laevis.
- Relationship between multidrug resistant gene expression and multidrug resistant-reversing effect of MS-209 in various tumor cells
- Scintigraphic detection of xenografted renal tumor by anti-renal cancer monoclonal antibody radiolabeled with technetium-99m.
- Molecular characterisation of a panel of human ovarian carcinoma xenografts.
- Multidrug resistance in human tumors--molecular diagnosis and clinical significance.
- MDR-1, but not MDR-3 gene expression, is associated with unmutated IgVH genes and poor prognosis chromosomal aberrations in chronic lymphocytic leukemia
- Profiles of Multidrug Resistance Protein-1 in the Peripheral Blood Mononuclear Cells of Patients with Refractory Epilepsy
- Cytotoxicity of the Sesquiterpene Lactones Neoambrosin and Damsin from Ambrosia maritima Against Multidrug-Resistant Cancer Cells
- Multidrug resistance: clinical findings and implications.
- In vitro models of multiple drug resistance.
- Biology and treatment of childhood T-lineage acute lymphoblastic leukemia.
- Mechanisms of drug resistance in AML.
- Transcriptional regulation of multidrug resistance gene expression.
- Genetic diversity in Plasmodium falciparum.
- Enhancement of the cytotoxicity of MRP substrates by indomethacin and related compounds
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