Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells
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Summary
In vitro, melatonin concentration‐dependently inhibited the proliferation of PASMCs and the levels of phosphorylation of Akt and extracellular signal‐regulated kinases1/2 (ERK1/1) caused by hypoxia, suggesting that melatonin might potentially prevent HPH via anti‐inflammatory and antiproliferative mechanisms.
- Type
- dissertation
- Published
- 2014-11-01
- Cited by
- 89
- References
- 62
- OpenAlex
- https://openalex.org/W25251287
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9972000
Keywords
Ordinary least squares, Economics, Investment (military), Variables, Per capita
References
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Cited by
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- Melatonin as a preventive and curative therapy against pulmonary hypertension
- Adaptation and remodelling of the pulmonary circulation in pulmonary hypertension.
- Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep
- Melatonin reduces obesity and restores adipokine patterns and metabolism in obese (ob/ob) mice.
- Melatonin: the dawning of a treatment for fibrosis?
- SENP-1 enhances hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia-inducible factor-1α
- Effects of melatonin on cardiovascular diseases: progress in the past year
- Melatonin and Human Cardiovascular Disease
- Grape seed procyanidin extract attenuates hypoxic pulmonary hypertension by inhibiting oxidative stress and pulmonary arterial smooth muscle cells proliferation.
- A urotensin II receptor antagonist, KR36676, decreases vascular remodeling and inflammation in experimental pulmonary hypertension.
- Clinical Adverse Effects of Endothelin Receptor Antagonists: Insights From the Meta‐Analysis of 4894 Patients From 24 Randomized Double‐Blind Placebo‐Controlled Clinical Trials
- Lung injury and inflammation response by chronic intermittent hypoxia in rats
- Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats
- Melatonin promotes the proliferation of GC-1 spg cells by inducing metallothionein-2 expression through ERK1/2 signaling pathway activation
- Exogenous melatonin in the treatment of pain: a systematic review and meta-analysis
- Natural Antioxidants as Potential Therapy, and a Promising Role for Melatonin Against Pulmonary Hypertension.
- Up‐regulation of caveolin‐1 by DJ‐1 attenuates rat pulmonary arterial hypertension by inhibiting TGF&bgr;/Smad signaling pathway
- Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting vascular remodeling in rats.
- Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension by down-regulating HSP70.
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