Genistein‐induced neuroendocrine differentiation of prostate cancer cells
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Summary
This study studied the effect of the phytoestrogen, genistein, on NE differentiation of LNCaP cells in vitro and found that the number of NE cells appears to be increased in advanced prostate cancer (PCA).
- Type
- article
- Published
- 2006-08-01
- Cited by
- 42
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W16652383
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46566560
Keywords
Pleistocene, Geology, Japonica, Paleontology, Geography
References
- Cancer cell lines
- Elevation of cyclic adenosine 3',5'-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells.
- Genistein, a specific inhibitor of tyrosine-specific protein kinases.
- Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression.
- Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells
- Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis.
- Phase I pharmacokinetic and pharmacodynamic analysis of unconjugated soy isoflavones administered to individuals with cancer.
- Prediction of response to docetaxel by quantitative analysis of class I and III beta-tubulin isotype mRNA expression in human breast cancers.
- Antioxidant and Antipromotional Effects of the Soybean Isoflavone Genistein
- Transdifferentiation of cultured human prostate cancer cells to a neuroendocrine cell phenotype in a hormone-depleted medium.
- Neuroendocrine differentiation in prostate cancer: implications for new treatment modalities.
- Modulation of neuroendocrine differentiation in prostate cancer by interleukin‐1 and ‐2
- Soy intake and cancer risk: a review of the in vitro and in vivo data.
- Interleukin-6 induces G1 arrest through induction of p27(Kip1), a cyclin-dependent kinase inhibitor, and neuron-like morphology in LNCaP prostate tumor cells.
- Mechanisms of taxotere-related drug resistance in pancreatic carcinoma.
- Development of human prostate cancer cells to neuroendocrine-like cells by interleukin-1.
- The role of soy phytoestrogens in prostate cancer
- Genistein induces cell growth inhibition in prostate cancer through the suppression of telomerase activity
- IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3.
- Androgen‐independent growth is induced by neuropeptides in human prostate cancer cell lines
Cited by
- Triiodothyronine Attenuates Prostate Cancer Progression Mediated by β-Adrenergic Stimulation
- Neurotransmitter effects on tumor cells and leukocytes.
- Clinical pharmacology of isoflavones and its relevance for potential prevention of prostate cancer.
- Impact of genistein on maturation of mouse oocytes, fertilization, and fetal development.
- Genistein combined polysaccharide enhances activity of docetaxel, bicalutamide and Src kinase inhibition in androgen‐dependent and independent prostate cancer cell lines
- Aneugenic effects of the genistein glycosidic derivative substituted at C7 with the unsaturated disaccharide
- Enhancement of TRAIL-Mediated Apoptosis by Genistein in Human Hepatocellular Carcinoma Hep3B Cells: Roles of p38 MAPK Signaling Pathway
- Pigment epithelium-derived factor and interleukin-6 control prostate neuroendocrine differentiation via feed-forward mechanism.
- Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells.
- Neuroendocrine differentiation is involved in chemoresistance induced by EGF in prostate cancer cells.
- Genistein sensitizes TRAIL-resistant human gastric adenocarcinoma AGS cells through activation of caspase-3.
- The effects of short-term genistein intervention on prostate biomarker expression in patients with localised prostate cancer before radical prostatectomy
- Significance of Serum Calcitonin Gene-Related Peptide Levels in Prostate Cancer Patients Receiving Hormonal Therapy
- Induction of Apoptosis by Combined-treatment with Genistein and TRAIL in U937 Human Leukemia Cells
- Recombinant Human IFN-β Affects Androgen Receptor Level, Neuroendocrine Differentiation, Cell Adhesion, and Motility in Prostate Cancer Cells
- Genistein sensitizes human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by enhancing Bid cleavage
- Gene profiling and pathway analysis of neuroendocrine transdifferentiated prostate cancer cells
- Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma
- Analysis of Phyotoestrogens in the aquatic environment using liquid chromatography/ electrospray ionization ion trap mass spectrometry
- The relationship of neuroendocrine carcinomas to anti‐tumor therapies in TRAMP mice
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