Pharmacokinetic Approach to Rational Therapeutic Doses for Human Tumor‐bearing Nude Mice
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Summary
The results suggest that the antitumor effects of most anti-tumor agents are over‐ or underestimated in this model when MTD's are used as a therapeutic dose, and indicate that the use of clinically equivalent doses determined pharmacokinetically isdesirable.
- Type
- article
- Published
- 1988-04-01
- Cited by
- 36
- References
- 9
- Access
- Open access
- OpenAlex
- https://openalex.org/W2001865989
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13715864
Keywords
Pharmacokinetics, Pharmacology, Methotrexate, Medicine, Vincristine
References
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- Clinical pharmacokinetics of vinblastine by continuous intravenous infusion.
- Lack of effect of methotrexate on human head and neck tumours transplanted in athymic nude mice.
- Chemosensitivity of human head and neck cancer xenografts in the clonogenic assay and in nude mice.
- Cytocidal action of anticancer antigens: evaluation of the sensitivity of cultured animal and human cancer cells.
- The pharmacokinetics of [3H]‐vincristine in man
- Comparative Studies on the Blood Level, Tissue Distribution, Excretion and Inactivation of Anticancer Drugs
- [Determination of adriamycin and its metabolites in biological samples using high performance liquid chromatography. I. Analysis of serum and plasma by direct injection method].
- TECHNIQUES FOR STUDY OF RESISTANCE TO FOLIC ACID ANTAGONISTS.
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- UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice.
- Human Primary Tumorgraft Models: Comparisons with Traditional Oncology Pre-Clinical Models and The Clinical Relevance and Utility of Primary Tumorgrafts in Basic and Translational Oncology Research
- Modulació de la sensibilitat a la gemcitabina mitjançant estratègies de teràpia gènica en càncer de pàncreas humà.
- Proliferation assay on a silicon chip applicable for tumors extirpated from mammalians
- P-31 changes as a measure of therapy response in resistant and sensitive osteosarcomas implanted into nude mice.
- 31P changes as a measure of therapy response in human osteosarcomas implanted into nude mice.
- Issues in experimental design and endpoint analysis in the study of experimental cytotoxic agents in vivo in breast cancer and other models
- Preclinical recapitulation of antiangiogenic drug clinical efficacies using models of early or late stage breast cancer metastatis.
- Opiate effects on 5-fluorouracil disposition in mice
- Responsiveness of human lung cancer/nude mouse to antitumor agents in a model using clinically equivalent doses
- Re: Relationship between topotecan systemic exposure and tumor response in human neuroblastoma xenografts.
- Experimental models of hepatocellular carcinoma.
- Experimental chemotherapy against canine mammary cancer xenograft in SCID mice and its prediction of clinical effect.
- Responsiveness of Human Gastric Tumors Implanted in Nude Mice to Clinically Equivalent Doses of Various Antitumor Agents
- Prediction of the maximal tolerated dose (MTD) and therapeutic effect of anticancer drugs in humans: integration of pharmacokinetics with pharmacodynamics and toxicodynamics.
- Evaluation of antitumor activity in a human breast tumor/nude mouse model with a special emphasis on treatment dose
- Prediction of ACNU plasma concentration-time profiles in humans by animal scale-up
- P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo.
- Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
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