MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer
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Summary
Downregulation of microRNA-497 (miR-497) as a result of DNA copy number reduction is involved in upregulation of IGF1-R in CRC cells that contributes to malignancy of CRC.
- Type
- article
- Published
- 2012-06-18
- Cited by
- 227
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W2073910094
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22892331
Keywords
Downregulation and upregulation, Biology, Cancer research, microRNA, Growth factor receptor
References
- The new kid on the block(ade) of the IGF-1 receptor.
- MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma.
- Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab
- Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice
- Non-coding MicroRNAs hsa-let-7g and hsa-miR-181b are Associated with Chemoresponse to S-1 in Colon Cancer.
- MicroRNA Expression Variability in Human Cervical Tissues
- microRNAs exhibit high frequency genomic alterations in human cancer.
- The emerging important role of microRNAs in the pathogenesis, diagnosis and treatment of human cancers
- Insulin‐like growth factor I receptor is required for the mitogenic and transforming activities of the platelet‐derived growth factor receptor
- microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells.
- miR-15 and miR-16 induce apoptosis by targeting BCL2.
- Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress
- Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).
- MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
- MicroRNA signatures in human cancers
- The PI3K pathway as drug target in human cancer.
- Overexpression of the insulin‐like growth factor I receptor in human colon carcinomas
- miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia
- Role of miR-143 targeting KRAS in colorectal tumorigenesis
- Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma
Cited by
- MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1
- MicroRNAs as Regulator of Signaling Networks in Metastatic Colon Cancer
- The NF-κB-modulated microRNAs miR-195 and miR-497 inhibit myoblast proliferation by targeting Igf1r, Insr and cyclin genes
- Involvement of Non-coding RNAs in Chemo- and Radioresistance of Colorectal Cancer.
- A two-microRNA-based signature predicts first-line chemotherapy outcomes in advanced colorectal cancer patients
- Down-regulation of miR-497 is associated with poor prognosis in renal cancer.
- Knockdown of type I insulin-like growth factor receptor inhibits human colorectal cancer cell growth and downstream PI3K/Akt, WNT/β-catenin signal pathways.
- Overexpression of miRNA-497 inhibits tumor angiogenesis by targeting VEGFR2
- Upregulation of miR-497 induces hepatic insulin resistance in E3 rats with HFD-MetS by targeting insulin receptor.
- The Down-Regulation of MicroRNA-497 Contributes to Cell Growth and Cisplatin Resistance Through PI3K/Akt Pathway in Osteosarcoma
- MicroRNAs: promising biomarkers for diagnosis and therapeutic targets in human colorectal cancer metastasis
- Identification of microRNAs Specifically Expressed in Hepatitis C Virus-Associated Hepatocellular Carcinoma
- Post-transcriptional regulation of BRCA1 through its coding sequence by the miR-15/107 group of miRNAs
- miR-199a and miR-497 Are Associated with Better Overall Survival due to Increased Chemosensitivity in Diffuse Large B-Cell Lymphoma Patients
- Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers
- Identification of Recurrence-Related microRNAs from Bone Marrow in Hepatocellular Carcinoma Patients
- MicroRNA–mRNA interactions in colorectal cancer and their role in tumor progression
- MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1
- MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells.
- MiR-497 downregulation contributes to the malignancy of pancreatic cancer and associates with a poor prognosis
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