Overexpression of the insulin‐like growth factor I receptor in human colon carcinomas
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Summary
High concentrations of insulin‐like growth factor (IGF)‐I and IGF‐II have been demonstrated in human colonic adenocarcinomas and exert mitogenic effects through paracrine/autocrine interactions with the IGF‐I receptor (IGf‐IR).
- Type
- article
- Published
- 2002-11-15
- Cited by
- 176
- References
- 50
- OpenAlex
- https://openalex.org/W2009876678
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23602437
Keywords
Autocrine signalling, Immunohistochemistry, Paracrine signalling, Receptor, Growth factor
References
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- Role of insulin-like growth factor-I (IGF-I) receptor, IGF-I, and IGF binding protein-2 in human colorectal cancers.
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
- Growth regulation and co-stimulation of human colorectal cancer cell lines by insulin-like growth factor I, II and transforming growth factor alpha.
- Quantification of the full length leptin receptor (OB-Rb) in human brown and white adipose tissue.
- Possible paracrine mechanism of insulin‐like growth factor‐2 in the development of liver metastases from colorectal carcinoma
- Constitutive or inducible overexpression of the IGF-2 gene in cells of a human colon carcinoma cell line.
- Expression of type I, but not type II insulin-like growth factor receptor on both undifferentiated and differentiated HT29 human colon carcinoma cell line.
- Cell polarity of the insulin-like growth factor system in human intestinal epithelial cells. Unique apical sorting of insulin-like growth factor binding protein-6 in differentiated human colon cancer cells.
- Expression of the insulin-like growth factors and their receptors in adenocarcinoma of the colon
- Alterations in serum levels of insulin‐like growth factors and insulin‐like growth‐factor‐binding proteins in patients with colorectal cancer
- Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers.
- Expression of insulin-like growth factor-1 receptor in human colorectal cancer.
- Insulin-like Growth Factors and Cancer
Cited by
- Improving the response to molecular targeting of the TRAIL death receptors in colon cancer cells
- Introduction: Uveal melanoma
- Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab
- GSK1838705A, an insulin-like growth factor-1 receptor/insulin receptor inhibitor, induces apoptosis and reduces viability of docetaxel-resistant prostate cancer cells both in vitro and in vivo
- Insulin-like growth factor (IGF) axis in cancerogenesis.
- Increased susceptibility to experimental steatohepatitis induced by methionine-choline deficiency in HBs-Tg mice.
- Effects of insulin resistance on myometrial growth.
- Insulin therapy in diabetes and cancer risk: Current understanding and implications for future study
- Metabolic syndrome and cancer: from bedside to bench and back.
- Análise da expressão e do silenciamento do receptor tipo 1 do fator de crescimento semelhante à insulina em tumores adrenocorticais humanos
- The insulin-like growth factor (IGF) axis as an anticancer target in prostate cancer.
- The Insulin-like Growth Factor (IGF) system in breast and colorectal carcinogenesis: dietary intervention and molecular studies
- Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: Clinical implications
- [The role of insulin-like growth factors (IGF) in cell division processes and in malignancy].
- Ectopic virilising adrenocortical tumour in the spinal region in an 8 year-old boy: a case report and review of the literature
- Clinical significance of IGF1R gene expression in patients with Stage II/III gastric cancer who receive curative surgery and adjuvant chemotherapy with S-1
- Curcumol Inhibits Growth and Induces Apoptosis of Colorectal Cancer LoVo Cell Line via IGF-1R and p38 MAPK Pathway
- An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation.
- Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells.
- Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer.
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