miR-15 and miR-16 induce apoptosis by targeting BCL2.
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Summary
It is demonstrated thatmiR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate BCL2 at a posttranscriptional level and are natural antisense B cl2 interactors that could be used for therapy of Bcl1-overexpressing tumors.
- Type
- article
- Published
- 2005-09-27
- Cited by
- 3,843
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W1985563073
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33559078
Keywords
microRNA, Chronic lymphocytic leukemia, Cancer research, Leukemia, Biology
References
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- Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
- Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia
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- Inhibidors de cinases com a estratègia terapèutica en neoplàsies limfoides
- microRNAs in Cancer: biological effects of microRNAs in colorectal cancer
- CRSD: a comprehensive web server for composite regulatory signature discovery
- Analyzing micro-RNA expression using microarrays.
- Contingent microARN des exosomes, diagnostic et physiopathologie des gliomes
- MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
- Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice.
- miRNAs in cancer: approaches, aetiology, diagnostics and therapy.
- Translational Medicine: microRNAs: a new emerging class of players for disease diagnostics and gene therapy
- Prognosis and therapy of chronic lymphocytic leukemia and small lymphocytic lymphoma.
- Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14.
- p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation
- Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas.
- BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations
- The role of microRNA in human leukemia: a review
- MicroRNAs in breast cancer
- Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro.
- Regulation of p27(kip1) mRNA expression by microRNAs.
- Ribosome‐associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia
- miR signatures and the role of miRs in acute myeloid leukaemia.
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