Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab
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Summary
A novel role for IGF-1 is identified in the enrichment of chemo-resistant CSC populations in colon cancer cell lines in vitro and in vivo and may complement current standard chemotherapeutic regimens that target cycling cells.
- Type
- article
- Published
- 2011-07-15
- Cited by
- 64
- References
- 44
- Access
- Open access
- OpenAlex
- https://openalex.org/W21720213
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9622519
Keywords
Computer science
References
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- Characterization of a subpopulation of colon cancer cells with stem cell‐like properties
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- Prospective identification of tumorigenic breast cancer cells
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- Identification and expansion of human colon-cancer-initiating cells
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- Signaling pathways in HPV‐associated cancers and therapeutic implications
- Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response
- Resveratrol overcomes TRAIL resistance in human colon cancer cells
- Role of CD133 in colorectal cancer
- Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on β-catenin
- Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo
- Role of Environmental Chemicals, Processed Food Derivatives, and Nutrients in the Induction of Carcinogenesis
- Interpretation of interlocking key issues of cancer stem cells in malignant solid tumors
- Mesenchymal stem cells: from experiment to clinic
- Developmental pathways in colon cancer
- The Emerging Role of Insulin and Insulin-Like Growth Factor Signaling in Cancer Stem Cells
- MicroRNA-143 inhibits tumor growth and angiogenesis and sensitizes chemosensitivity to oxaliplatin in colorectal cancers
- Krüppel-Like Factor 4 Acts as an Oncogene in Colon Cancer Stem Cell-Enriched Spheroid Cells
- Monoclonal antibodies against human cancer stem cells.
- The role of the insulin-like growth factor-I receptor in malignancy: an update.
- Inhibition of IGF‐IR increases chemosensitivity in human colorectal cancer cells through MRP‐2 promoter suppression
- MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer
- Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach
- The differentiation of pancreatic tumor-initiating cells by vitronectin can be blocked by Cilengitide
- YAP oncogene overexpression supercharges colon cancer proliferation
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