Osteoblastic cells regulate the haematopoietic stem cell niche
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Summary
Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
- Type
- article
- Published
- 2003-10-23
- Cited by
- 3,640
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W2070793750
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4420897
Keywords
Stem cell, Haematopoiesis, Cell biology, Stromal cell, Bone marrow
References
- Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
- Stem cells find their niche
- Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures.
- The relative spatial distributions of CFUs and CFUc in the normal mouse femur.
- Somatic support cells restrict germline stem cell self-renewal and promote differentiation
- Somatic control over the germline stem cell lineage during Drosophila spermatogenesis
- Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
- The relationship between the spleen colony-forming cell and the haemopoietic stem cell.
- Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells.
- Identification of the haematopoietic stem cell niche and control of the niche size
- The architecture of bone marrow cell populations.
- Endosteal marrow: a rich source of hematopoietic stem cells.
- Hepatocyte growth factor is secreted by osteoblasts and cooperatively permits the survival of haematopoietic progenitors
- The relative spatial distribution of in vitro‐CFCs in the bone marrow, responding to specific growth factors
- Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
- The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.
- Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome.
- Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.
- The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells
- The effects of SCF/G-CSF prestimulation on radiation sensitivity and engraftment in nonmyeloablated murine hosts.
Cited by
- In vitro construction of 2D and 3D simulations of the murine hematopoietic niche.
- Advances in Cancer Stem Cell Biology
- Review Article Stem Cells, Phenotypic Inversion, and Differentiation
- Analysis of EF-hand-containing proteins in Arabidopsis
- Regulation of haematopoiesis by growth factors – emerging insights and therapies
- Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity.
- Identification of hematopoietic stem/progenitor cells: strength and drawbacks of functional assays
- Autocrine transforming growth factor-β regulation of hematopoiesis: many outcomes that depend on the context
- Multicellular spheroids of bone marrow stromal cells: a three-dimensional in vitro culture system for the study of hematopoietic cell migration.
- The role of T lymphocytes in bone metabolism
- Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain.
- In vitro expansion of long‐term repopulating hematopoietic stem cells in the presence of immobilized Jagged‐1 and early acting cytokines
- Regulation of hematopoietic niches by sympathetic innervation.
- Stromal regulation of hemopoietic stem cells in long-term human bone marrow tissue cultures under the effect of parathyroid hormone
- Cytokine Signaling, Lipid Raft Clustering, and HSC Hibernation
- Co-culture of cord blood CD34(+) cells with human BM mesenchymal stromal cells enhances short-term engraftment of cord blood cells in NOD/SCID mice.
- Senescence-unrelated impediment of osteogenesis from Flk1+ bone marrow mesenchymal stem cells induced by total body irradiation and its contribution to long-term bone and hematopoietic injury.
- Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival.
- Ex vivo expansions of megakaryocytopoiesis from placental and umbilical cord blood CD34(+) cells in serum-free culture supplemented with proteoglycans extracted from the nasal cartilage of salmon heads and the nasal septum cartilage of whale.
- Surface-dependent modulation of proliferation, bone matrix molecules, and inflammatory factors in human osteoblasts.
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