In vitro expansion of long‐term repopulating hematopoietic stem cells in the presence of immobilized Jagged‐1 and early acting cytokines
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Summary
A role for combinatorial effects by Notch and cytokine‐induced signaling pathways in regulating hematopoietic stem cell fate and to a potential role for Notch ligand in increasing cell numbers in clinical stem cell transplantation are supported.
- Type
- article
- Published
- 2006-05-01
- Cited by
- 24
- References
- 20
- OpenAlex
- https://openalex.org/W16621624
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33932341
Keywords
Law, Russian federation, Political science, Supreme court, Value (mathematics)
References
- The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells.
- Chimerism analysis in sex-mismatched murine transplantation using quantitative real-time PCR.
- Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.
- A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells.
- Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
- Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
- Notch signaling: control of cell communication and cell fate
- Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome.
- Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells.
- Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.
- The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells
- Notch receptors and hematopoiesis.
- Osteoblastic cells regulate the haematopoietic stem cell niche
- A role for Wnt signalling in self-renewal of haematopoietic stem cells
- Soluble Jagged‐1 is able to inhibit the function of its multivalent form to induce hematopoietic stem cell self‐renewal in a surrogate in vitro assay
- HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo.
- Notch signaling: cell fate control and signal integration in development.
- A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors.
- Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells.
Cited by
- Endothelial‐to‐hematopoietic transition: Notch‐ing vessels into blood
- Live and Let Die : Critical regulation of survival in normal and malignant hematopoietic stem and progenitor cells
- Orientation-regulated immobilization of Jagged1 on glass substrates for ex vivo proliferation of a bone marrow cell population containing hematopoietic stem cells.
- Biomaterials Design of Culture Substrates for Cell Research
- An Interdisciplinary Approach and Characterization of Neuronal Cells Transdifferentiated from Human Mesenchymal Stem Cells
- Retronectin enhances lentivirus-mediated gene delivery into hematopoietic progenitor cells.
- The hematopoietic stem cell niche: what are we trying to replicate?
- Mimicking Stem Cell Niches to Increase Stem Cell Expansion
- Strategies to enhance umbilical cord blood stem cell engraftment in adult patients
- Designing and Engineering Stem Cell Niches
- Biological modifications of materials surfaces with proteins for regenerative medicine
- Rational design of gold nanocarrier for the delivery of JAG-1 peptide
- Distinguishing autocrine and paracrine signals in hematopoietic stem cell culture using a biofunctional microcavity platform
- Developments in Hematopoietic Stem Cell Expansion and Gene Editing Technologies.
- The C. elegans Notch proteins LIN-12 and GLP-1 are tuned to lower force thresholds for activation than Drosophila Notch
- Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins
- Cell Biology and Translational Medicine, Volume 1
- Expansion of Human Hematopoietic Stem Cells
- Chapter Forty-Nine – Hematopoietic Stem Cells
- 4.19 Growth Factors and Protein-Modified Surfaces and Interfaces☆
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