The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.
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Summary
Observations suggest that hJagged1 may function as a ligand for Notch1 and play a role in mediating cell fate decisions during hematopoiesis.
- Type
- article
- Published
- 1998-01-01
- Cited by
- 299
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W2031018864
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46700744
Keywords
Biology, Stromal cell, Haematopoiesis, Cell biology, Bone marrow
References
- A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis.
- Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes.
- Homologs of vertebrate growth factors in Drosophila melanogaster and other invertebrates.
- Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line.
- The involvement of the Notch locus in Drosophila oogenesis.
- Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta.
- Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
- A homolog of Drosophila Notch expressed during mammalian development.
- Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development.
- Choosing a cell fate: a view from the Notch locus.
- A dual function of the Notch gene in Drosophila sensillum development.
- Mouse notch: expression in hair follicles correlates with cell fate determination
- Jagged: a mammalian ligand that activates Notch1.
- Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.
- Expression of a Delta homologue in prospective neurons in the chick
- Developmental Signalling: Vertebrate ligands for Notch
- Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs.
- Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin
- Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta
- Jagged2: a serrate-like gene expressed during rat embryogenesis.
Cited by
- The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells.
- Notch signalling via RBP‐J promotes myeloid differentiation
- Identification, Isolation, and Culture of Intestinal Epithelial Stem Cells from Murine Intestine
- Chimeric SCID-hu Model as a Human Hematopoietic Stem Cell Host That Recapitulates the Effects of HIV-1 on Bone Marrow Progenitors in Infected Patients.
- Hematological malignancies: disease pathophysiology of leukemic stem cells.
- Notch in malignancy.
- Hematopoietic Stem Cell Threshold Sensing Controls Regulatory Pathways Facilitating Clinically Relevant Ex Vivo Expansion for Stem Cell Transplantation
- Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1.
- Notch signaling and development of the hematopoietic system.
- The role of the notch and hedgehog signalling pathways in vascular smooth muscle cell growth
- Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.
- Homing of hematopoietic progenitor cells to the bone marrow
- Therapy of Prostate Cancer Using a Human Antibody Targeting the Type 1 Insulin-Like Growth Factor Receptor (IGF-IR)
- The role of the notch signalling pathway in vascular smooth muscle cell apoptosis
- Novel drug therapies in myeloid leukemia.
- Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact.
- Genetic engineering of mesenchymal stem cells
- New roles of STAT5 factors in chronic myeloid leukemia cell maintenance
- Notch signalling pathway in murine embryonic stem cell derived haematopoiesis
- Evaluation in vitro de la fonction hématopoïétique des cellules souches mésenchymateuses médullaires au cours de leur différenciation
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