The genetics of ageing
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Summary
The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live for 100 years or more, which means that over evolutionary time mutations have increased lifespan more than 2,000-fold.
- Type
- review
- Published
- 2010-03-24
- Cited by
- 2,762
- References
- 103
- OpenAlex
- https://openalex.org/W2058484936
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2781311
Keywords
Ancestor, Caenorhabditis elegans, Biology, Nematode, Evolutionary biology
References
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Cited by
- Can biogerontologists and geriatricians unite to apply aging science to health care in the decade ahead?
- An aging program at the systems level?
- The Free Radical Theory of Aging In Search of a Strategy for Increasing Life Span / Свободнорадикальная Теория О Старении В Поиске Стратегии Увеличить Продолжительность Жизни
- Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?
- Ubiquitin sets the timer: impacts on aging and longevity
- Why Is Aging Conserved and What Can We Do about It?
- Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans
- Calorie restriction as an intervention in ageing
- Aging Biology in the Kidney.
- How a mutation that slows aging can also disproportionately extend end-of-life decrepitude
- CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans
- Drosophila larvae fed palm fruit juice (PFJ) delay pupation via expression regulation of hormetic stress response genes linked to ageing and longevity
- The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response.
- DAF-21/Hsp90 is required for C. elegans longevity by ensuring DAF-16/FOXO isoform A function
- Reproductive experience may positively adjust the trajectory of senescence.
- A method for high-throughput analysis of chronological aging in Schizosaccharomyces pombe.
- Lithocholic Acid and Macromitophagy Regulate the Dynamics of Lipid Metabolism and Storage to Modulate Chronological Aging in Saccharomyces cerevisiae
- Comparison of ZnO nanoparticles and ZnCl2 induced germ cell apoptosis in Caenorhabditis elegans
- Dynamic regulation of genetic pathways and targets during aging in Caenorhabditis elegans
- Using the Experimental Evolution of Long-Lived Yeast Species for Testing Evolutionary Theories of Aging
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