Calorie Restriction Effects on Silencing and Recombination at the Yeast rDNA

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Summary

It is shown that in contrast to previous reports, Sir2 is not stimulated by CR to strengthen silencing of multiple reporter genes in the rDNA of S. cerevisiae, and CR does modestly reduce the frequency of rDNA recombination, although in a SIR2‐independent manner.

Type
article
Published
2009-09-02
Cited by
44
References
68
Access
Open access

Keywords

Biology, Gene silencing, Saccharomyces cerevisiae, Genetics, Calorie restriction

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