Calorie Restriction Effects on Silencing and Recombination at the Yeast rDNA
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Summary
It is shown that in contrast to previous reports, Sir2 is not stimulated by CR to strengthen silencing of multiple reporter genes in the rDNA of S. cerevisiae, and CR does modestly reduce the frequency of rDNA recombination, although in a SIR2‐independent manner.
- Type
- article
- Published
- 2009-09-02
- Cited by
- 44
- References
- 68
- Access
- Open access
- OpenAlex
- https://openalex.org/W1975648577
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23910661
Keywords
Biology, Gene silencing, Saccharomyces cerevisiae, Genetics, Calorie restriction
References
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- Methods in yeast genetics
- Linker histone H1 represses recombination at the ribosomal DNA locus in the budding yeast Saccharomyces cerevisiae
- The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.
- Extrachromosomal rDNA circles--a cause of aging in yeast.
- A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance
- Identification and functional analysis of the Saccharomyces cerevisiae nicotinamidase gene, PNC1
- The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
- An intervention resembling caloric restriction prolongs life span and retards aging in yeast
- Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction"
- Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
- Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
- Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast.
- HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction
- Sir2 mediates longevity in the fly through a pathway related to calorie restriction.
- Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.
- Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
- Sir2-Independent Life Span Extension by Calorie Restriction in Yeast
- Recombination Regulation by Transcription-Induced Cohesin Dissociation in rDNA Repeats
- Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
Cited by
- Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance.
- Aging Research in Yeast
- Caractérisation de la fonction des complexes histone déacétylases Rpd3S et Set3C
- DNA damage and DNA replication stress in yeast models of aging.
- Genome-wide analysis of yeast aging.
- The fine line between lifespan extension and shortening in response to caloric restriction
- Caloric restriction: from soup to nuts.
- Enforcement of a lifespan‐sustaining distribution of Sir2 between telomeres, mating‐type loci, and rDNA repeats by Rif1
- N-alpha-terminal Acetylation of Histone H4 Regulates Arginine Methylation and Ribosomal DNA Silencing
- Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies
- Transgenerational Inheritance of Diet-Induced Genome Rearrangements in Drosophila
- A budding yeast's perspective on aging: The shape I'm in
- Isonicotinamide Enhances Sir2 Protein-mediated Silencing and Longevity in Yeast by Raising Intracellular NAD+ Concentration*
- Calorie restriction reduces rDNA recombination independently of rDNA silencing
- Perspectives on the mitochondrial etiology of replicative aging in yeast.
- The genetics of ageing
- Calorie Restriction: What Recent Results Suggest for the Future of Aging Research
- Lessons on longevity from budding yeast
- NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity
- Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging.
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