CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans
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Summary
It is demonstrated that CGEF-1, the C. elegans homolog of the human guanine nucleotide exchange factor Dbl, is a novel binding partner of RHEB-1 and activator of mTORC1 signaling in cgef-1 mutants, which has important implications for mTOR functions and signaling mechanisms in aging and age-related diseases.
- Type
- article
- Published
- 2015-07-18
- Cited by
- 6
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W29515755
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3758835
Keywords
Political science
References
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Cited by
- CBP-1/p300 acetyltransferase regulates SKN-1/Nrf cellular levels, nuclear localization, and activity in C. elegans.
- TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging
- Silencing of the mitochondrial ribosomal protein L-24 gene activates the oxidative stress response in Caenorhabditis elegans.
- Nurturing longevity through natural compounds: Where do we stand, and where do we go?
- Astaxanthin promotes the longevity of Caenorhabditis elegans via modulation of the intracellular redox status and PHA-4-mediated autophagy.
- Aging in the Nematode Caenorhabditis elegans
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