FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
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Summary
Using quantitative assays, it is shown that kinases and adaptor molecules, including focal adhesion kinase, Src, p130CAS, paxillin, extracellular signal-regulated kinase and myosin light-chain kinase are critical for adhesion turnover at the cell front, a process central to migration.
- Type
- article
- Published
- 2004-01-25
- Cited by
- 1,446
- References
- 43
- OpenAlex
- https://openalex.org/W2048209624
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8978511
Keywords
Paxillin, Focal adhesion, Cell biology, Proto-oncogene tyrosine-protein kinase Src, Cell adhesion
References
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- Paxillin and focal adhesion signalling
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- Cell migration: a physically integrated molecular process.
- Phosphorylation of Tyrosine 397 in Focal Adhesion Kinase Is Required for Binding Phosphatidylinositol 3-Kinase*
- Characterization of Tyrosine Phosphorylation of Paxillin in Vitro by Focal Adhesion Kinase (*)
- The Cytoskeletal/Non-muscle Isoform of α-Actinin Is Phosphorylated on Its Actin-binding Domain by the Focal Adhesion Kinase*
- Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis.
- The Role of Focal Adhesion Kinase Binding in the Regulation of Tyrosine Phosphorylation of Paxillin*
- Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions
- Localized Rac activation dynamics visualized in living cells.
- PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation
- Signaling through focal adhesion kinase.
- Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again
- Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
- Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion*
- Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration
Cited by
- The role and regulation of PAK isoforms in cancer cell migration
- The Epstein-Barr Virus-Encoded LMP2A and LMP2B Proteins Promote Epithelial Cell Spreading and Motility
- Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways.
- Lactoferrin promotes collagen gel contractile activity of fibroblasts mediated by lipoprotein receptors.
- CAP interacts with cytoskeletal proteins and regulates adhesion‐mediated ERK activation and motility
- Erk1/2 MAPK and caldesmon differentially regulate podosome dynamics in A7r5 vascular smooth muscle cells.
- Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids.
- Therapeutic strategies for inhibiting invasion in glioblastoma
- The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin.
- Expression of Mutant α1 Na/K-ATPase Defective in Conformational Transition Attenuates Src-mediated Signal Transduction*
- LKB1 Represses Focal Adhesion Kinase (FAK) Signaling via a FAK-LKB1 Complex to Regulate FAK Site Maturation and Directional Persistence*
- Dissecting signaling through activation of specific Src-effector complexes in vivo
- A lateral signalling pathway coordinates shape volatility during cell migration
- Immediate early response protein 2 regulates hepatocellular carcinoma cell adhesion and motility via integrin β1-mediated signaling pathway.
- IL‐6 increases podocyte motility via MLC‐mediated focal adhesion impairment and cytoskeleton disassembly
- Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer
- MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells
- New insights into the dynamics of cell adhesions.
- Deoxycytidine kinase promotes the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.
- Focal adhesion kinase, a major regulator of oligodendrocyte morphological maturation and myelination
Related papers
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