Signaling through focal adhesion kinase.

Keywords

Focal adhesion, PTK2, Cell biology, Integrin, Paxillin

References

• p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase*淳 鷲尾, 聰一 畑, 清水 新井 — 1996
• The Related Adhesion Focal Tyrosine Kinase Forms a Complex with Paxillin in Hematopoietic Cells*Ruth López Alonso, Javier Martínez Bajo — 1996
• Cytotoxic T lymphocytes express a β3 integrin which can induce the phosphorylation of focal adhesion kinase and the related PYK‐2Dante Alighieri — 1997
• Integrin signaling: specificity and control of cell survival and cell cycle progression.Andrew M. Michael — 1997
• Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5W. Sheldon Ridge — 1997
• PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase.Vincent Ong, Yucong Duan, Mark Xu — 1998
• Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK.Ramesh K. Ganju, Parmesh Dutt, Lijun Wu — 1998
• Casting light on focal adhesionsJoan S. Brugge — 1998
• Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin‐dependent pathway.Martin A. Schwartz, Deniz Toksoz, Roya Khosravi‐Far — 1996
• Receptor protein tyrosine phosphatase alpha activates pp60c‐src and is involved in neuronal differentiation.Jeroen den Hertog, Cornelieke Pals, Maikel P. Peppelenbosch — 1993
• Tyrosine phosphorylation of pp125FAK by the aggregation of high affinity immunoglobulin E receptors requires cell adherence.Majed M. Hamawy, S. E. Mergenhagen, Reuben P. Siraganian — 1993
• Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1.A. Jacqueline Hunter, Yoji Shimizu — 1997
• Focal adhesion-associated proteins p125FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells.L.M. Fredrik Leeb-Lundberg, X.H. Song, Sandra A. Mathis — 1994
• Integrin-mediated cell adhesion activates mitogen-activated protein kinases.Qing Chen, Michael S. Kinch, Taichen Lin — 1994
• Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling.D H Crouch, Valerie J. Fincham, Margaret C. Frame — 1996
• Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.Kunio Matsumoto, Kunio Matsumoto, Takamitsu Nakamura — 1994
• Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain.Matvey Lukashev, Dean Sheppard, Robert Pytela — 1994
• A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK.Peter Chan, Steven B. Kanner, Gena S. Whitney — 1994
• T cell adhesion to P-selectin induces tyrosine phosphorylation of pp125 focal adhesion kinase and other substrates.Hermann Haller, Ulrich Kunzendorf, K Sacherer — 1997
• Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.Ian Zachary, James Sinnett‐Smith, Enrique Rozengurt — 1992

Cited by

• Src-family Tyrosine Kinases in Oogenesis, Oocyte Maturation, and Fertilization: An Evolutionary PerspectiveWilliam H. Kinsey — 2014
• Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricleChristopher Babbitt, Shaw‐Yung Shai, Alice E. Harpf — 2002
• Computational and experimental studies of protein kinase-inhibitor interactionsShun Zhu — 2011
• FAK integrates growth-factor and integrin signals to promote cell migrationMaría Pilar Celma Valero — 2000
• Modulation of Intestinal Permeability: A Novel and Innovative Approach for the Oral Delivery of Drugs, Macromolecules and AntigensMaría Sagrario Martínez Beloqui — 2000
• The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals陽三郎 及川 — 2001
• Roles for zebrafish focal adhesion kinase in notochord and somite morphogenesis.Clarissa A. Henry, Bryan D. Crawford, Yi‐Lin Yan — 2001
• The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin SignalingSmitha Sundaram, B.G. Eldridge — 2002
• The structural basis of localization and signaling by the focal adhesion targeting domain.Claudio Sartea — 2002
• Antiapoptotic Action of Focal Adhesion Kinase (FAK) Against Ionizing RadiationИгорь Николаевич Ионов — 2002
• Mechanisms of epidermal growth factor receptor activation after epithelial woundingEthan R. Block — 2010
• Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression.David G. Schultz — 2003
• DNA array analysis of altered gene expression in human leukocytes stimulated with soluble and particulate forms of Candida cell wall beta-glucan.直恒 多賀, 泰彦 大谷 — 2004
• Photosensitization with protoporphyrin IX inhibits attachment of cancer cells to a substratum.N.T.J. Huurman — 2004
• Src Utilizes Cas to Block Gap Junctional Communication Mediated by Connexin43*いつか 判治, 智美 中邨, 靖奈 小林 — 2007
• Essential role of Pyk2 and Src kinase activation in neuropeptide-induced proliferation of small cell lung cancer cellsGlen Dash — 2008
• Functional dissection of transformation by c‐Src and v‐SrcAmando Melón Ruiz de Gordejuela — 2007
• Effect of wild type PTEN gene on proliferation and invasion of multiple myeloma芳信 西園, 八郎 田畑, 光政 日吉 — 2010
• Recent advances in researches on the innate immunity of shrimp in China.П. Л. Кузнецов, В. М. Борзунов, В. К. Веревщиков — 2013
• Anoikis molecular pathways and its role in cancer progression.Antonio Rodríguez Moreno — 2013

Related papers

• Paxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinase.Marion A. Cooley, Jill M. Broome, Christoph Ohngemach — 2000
• Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation.Yu Shen, Michael D. Schaller — 1999
• Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related NonkinaseMichael D. Schaller, C. Ohngemach, Jill M. Broome — 2020
• The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillinIkuko Hayashi, Kristiina Vuori, Robert Liddington — 2002
• Phosphorylated paxillin and phosphorylated FAK constitute subregions within focal adhesions.Michaël Bachmann, Artiom Skripka, Kai Weißenbruch — 2022
• Specific decrease in the level of Hic‐5, a focal adhesion protein, during immortalization of mouse embryonic fibroblasts, and its association with focal adhesion kinaseKeiko Ishino, Joo-ri Kim Kaneyama, Motoko Shibanuma — 2000
• Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway.Michael C. Brown, Kip A. West, Christopher E. Turner — 2002
• Microinjection of protein tyrosine phosphatases into fibroblasts disrupts focal adhesions and stress fibers.Galen B. Schneider, Andrew Gilmore, Lewis H. Romer — 1998