The role of autophagy in neurodegenerative disease
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Summary
An overview of the role of autophagy in neurodegenerative disease is provided, focusing particularly on less frequently considered lysosomal clearance mechanisms and their considerable impact on disease.
- Type
- article
- Published
- 2013-08-01
- Cited by
- 1,997
- References
- 232
- OpenAlex
- https://openalex.org/W2043291430
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9152845
Keywords
Autophagy, Endocytic cycle, Endosome, Disease, Neurodegeneration
References
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- Pharmacological Chaperones for Misfolded Gonadotropin-Releasing Hormone Receptors
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- Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death
- Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
- Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking
- AKT suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy
Cited by
- Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits.
- Rapamycin Ester Analog CCI-779/Temsirolimus Alleviates Tau Pathology and Improves Motor Deficit in Mutant Tau Transgenic Mice
- Cln1 gene disruption in mice reveals a common pathogenic link between two of the most lethal childhood neurodegenerative lysosomal storage disorders.
- Targeting Protein Aggregation for the Treatment of Degenerative Diseases
- Adoptive Autophagy Activation: a Much-Needed Remedy Against Chemical Induced Neurotoxicity/Developmental Neurotoxicity
- Cholesterol-Lowering Effect of Octaarginine-Appended β-Cyclodextrin in Npc1-Trap-CHO Cells.
- Autophagy and Schizophrenia: A Closer Look at How Dysregulation of Neuronal Cell Homeostasis Influences the Pathogenesis of Schizophrenia
- Acidic intracellular Ca(2+) stores and caveolae in Ca(2+) signaling and diabetes.
- Dysregulated molecular pathways in amyotrophic lateral sclerosis–frontotemporal dementia spectrum disorder
- Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells.
- The Endolysosomal System and Proteostasis: From Development to Degeneration
- The Autophagy Lysosomal Pathway and Neurodegeneration
- Interferon gamma induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5
- Dexamethasone Downregulates Autophagy through Accelerated Turn-Over of the Ulk-1 Complex in a Trabecular Meshwork Cells Strain: Insights on Steroid-Induced Glaucoma Pathogenesis
- Monepantel induces autophagy in human ovarian cancer cells through disruption of the mTOR/p70S6K signalling pathway.
- Effet de la composition en macronutriments de l’aliment sur les mécanismes de contrôle de l’autophagie chez la truite arc-enciel (Oncorhynchus mykiss)
- Autophagy induction as a therapeutic strategy for neurodegenerative diseases.
- Pompe Disease: Literature Review and Case Series
- Dissecting human CNS gene expression
- Rôle des protéines SNARE au niveau de la vacuole bactérienne durant les phases précoces de l'infection par Yersinia pseudotuberculosis dans un contexte d'autophagie
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