Autophagy induction as a therapeutic strategy for neurodegenerative diseases.
Explore this paper's citation graph
Summary
Evidence in cells and in vivo demonstrates promising results in many disease models, in which autophagy upregulation is able to reduce the levels of toxic proteins, ameliorate signs of disease, and delay disease progression.
- Type
- review
- Published
- 2019-12-27
- Cited by
- 198
- References
- 271
- Access
- Open access
- OpenAlex
- https://openalex.org/W69881358
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:209518157
Keywords
Autophagy, Biology, Computational biology, Neuroscience, Cell biology
References
- Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study
- Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila.
- TOR signaling in growth and metabolism.
- Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
- Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
- Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.
- Inhibition of the Androgen Receptor by Antiandrogens in Spinobulbar Muscle Atrophy
- Effects of the Insulin Sensitizer Metformin in Alzheimer’s Disease: Pilot Data from a Randomized Placebo-Controlled Crossover Study
- Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease
- Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer's disease models.
- Calcium signalling: dynamics, homeostasis and remodelling
- α-Synuclein in Lewy bodies
- Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice
- Compromised autophagy and neurodegenerative diseases
- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy
- Induction of autophagy and inhibition of tumorigenesis by beclin 1
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
- VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
- Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy
Cited by
- Synergic Effects of Berberine and Curcumin on Improving Cognitive Function in an Alzheimer’s Disease Mouse Model
- Emerging New Concepts of Degrader Technologies
- Outside in: Roles of complement in autophagy
- Autophagy-related neurotoxicity is mediated via AHR and CAR in mouse neurons exposed to DDE.
- Zinc and Autophagy in Age-Related Macular Degeneration
- Mechanistic Insights of Astrocyte-Mediated Hyperactive Autophagy and Loss of Motor Neuron Function in SOD1L39R Linked Amyotrophic Lateral Sclerosis
- Amino acid homorepeats in proteins
- Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes
- Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases
- Druggable Sphingolipid Pathways: Experimental Models and Clinical Opportunities
- Histone Deacetylase 6 and the Disease Mechanisms of α-Synucleinopathies
- Endoplasmic reticulum stress and autophagy in HIV-1-associated neurocognitive disorders
- Natural Compounds and Autophagy: Allies Against Neurodegeneration
- Glycosphingolipids and neuroinflammation in Parkinson’s disease
- The Dynamic Proteome of Oligodendrocyte Lineage Differentiation Features Planar Cell Polarity and Macroautophagy Pathways
- Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies
- Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective
- Autophagy in Multiple Sclerosis: Two Sides of the Same Coin
- The neuroprotective effects of activated α7 nicotinic acetylcholine receptor against mutant copper–zinc superoxide dismutase 1-mediated toxicity
- Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity
Related papers
- ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ
- Bnip3 interacts with LC3 to induce selective removal of endoplasmic reticulum and mitochondria via autophagy
- Self-consumption: the interplay of autophagy and apoptosis
- Posttranslational Modifications of Autophagy-related Proteins
- Apoptosis regulation by autophagy gene 5.
- The Interplay of Autophagy and Non-Apoptotic Cell Death Pathways
- NBR1 enables autophagy-dependent focal adhesion turnover