Chemical Modification of the Multi-Target Neuroprotective Compound Fisetin
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Summary
A multi-tiered approach to screening that has allowed fisetin derivatives with significantly enhanced activity in an in vitro neuroprotection model while at the same time maintaining other key activities is described.
- Type
- article
- Published
- 2011-12-20
- Cited by
- 96
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W136988321
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11720714
Keywords
Chemistry, Neuroprotection, Fisetin, Chemical modification, Pharmacology
References
- VIP-related protection against lodoacetate toxicity in pheochromocytoma (PC12) cells
- Distinct Glycolysis Inhibitors Determine Retinal Cell Sensitivity to Glutamate-Mediated Injury
- Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin
- Heart Disease and Stroke Statistics—2011 Update
- Medicinal chemical properties of successful central nervous system drugs
- 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.
- Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal‐regulated kinase activation
- Fisetin Lowers Methylglyoxal Dependent Protein Glycation and Limits the Complications of Diabetes
- Modulation of the Pasteur effect in retinal cells: implications for understanding compensatory metabolic mechanisms.
- Therapeutic strategies for the treatment of stroke.
- Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.
- Syntheses of 5,6,7- and 5,7,8-trioxygenated 3',4'-dihydroxyflavones having alkoxy groups and their inhibitory activities against arachidonate 5-lipoxygenase.
- Structure-brain exposure relationships.
- Activation and inhibition of protein kinase C protect rat neuronal cultures against ischemia-reperfusion insult.
- Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.
- Potential neuroprotective drugs in cerebral ischemia: new saturated and polyunsaturated lipids coupled to hydrophilic moieties: synthesis and biological activity.
- A novel approach to screening for new neuroprotective compounds for the treatment of stroke.
- Regioselective hydroxylation of 2-hydroxychalcones by dimethyldioxirane towards polymethoxylated flavonoids
- Temporal and spatial dynamics of cerebral immune cell accumulation in stroke.
- Understanding the cardioprotective effects of flavonols: discovery of relaxant flavonols without antioxidant activity.
Cited by
- Synthesis of flavonoids and flavonoid-based designed multiple ligands for hypertension
- Biological and computational evaluation of resveratrol inhibitors against Alzheimer’s disease
- Alteration of epigenetic program to recover memory and alleviate neurodegeneration: prospects of multi-target molecules.
- Benzofuran–Chalcone Hybrids as Potential Multifunctional Agents against Alzheimer’s Disease: Synthesis and in vivo Studies with Transgenic Caenorhabditis elegans
- Inhibition of tumour cell growth by carnosine: some possible mechanisms
- Drug-Like Property Profiling of Novel Neuroprotective Compounds to Treat Acute Ischemic Stroke: Guidelines to Develop Pleiotropic Molecules
- Fisetin, a dietary flavonoid, attenuates hyperammonemia and improves circadian locomotor deficits, redox balance, and astrocytic markers in rats
- Back to the future with phenotypic screening.
- Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids
- Pd-catalyzed atom-economic couplings of triarylbismuth reagents with 2-bromo- and 2,6-dibromochromones and synthesis of medicinally important fisetin
- Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: a new target for a privileged structure.
- The role of autophagy in neurodegenerative disease
- Chronotherapeutic effect of fisetin on expression of urea cycle enzymes and inflammatory markers in hyperammonaemic rats
- An alternative approach to drug discovery for Alzheimer's disease dementia.
- Towards tropomyosin-related kinase B (TrkB) receptor ligands for brain imaging with PET: radiosynthesis and evaluation of 2-(4-[(18)F]fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one and 2-(4-([N-methyl-(11)C]-dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one.
- Characterization of the Neuroprotective Potential of Derivatives of the Iron Chelating Drug Deferiprone
- Screening and identification of neuroprotective compounds relevant to Alzheimer׳s disease from medicinal plants of S. Tomé e Príncipe.
- Fisetin Enhances Behavioral Performances and Attenuates Reactive Gliosis and Inflammation During Aluminum Chloride-Induced Neurotoxicity
- Regulatory Effects of Fisetin on Microglial Activation
- Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Src and Syk
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