AKT suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy
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Summary
It is shown that acute retrograde axon degeneration is regulated by Akt/Rheb/mTor signaling pathways, and that deletion of the essential autophagy mediator Atg7 in adult mice achieves striking axon protection in these acute models of retrograde degeneration.
- Type
- article
- Published
- 2011-02-09
- Cited by
- 134
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1966055049
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15690377
Keywords
PI3K/AKT/mTOR pathway, RHEB, Protein kinase B, Neuroscience, Axon
References
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- Clinical Progression in Parkinson's Disease and the Neurobiology of Axons
- The WldS mutation delays anterograde, but not retrograde, axonal degeneration of the dopaminergic nigro-striatal pathway in vivo
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- Autophagy fights disease through cellular self-digestion
- The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.
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- Axonal Self-Destruction and Neurodegeneration
- Control of synaptic strength, a novel function of Akt.
- Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease.
- Loss of autophagy in the central nervous system causes neurodegeneration in mice
- LYSOSOMAL ACTIVITY ASSOCIATED WITH DEVELOPMENTAL AXON PRUNING
- Induction of Autophagy Causes Dramatic Changes in the Subcellular Distribution of GFP‐Rab24
Cited by
- It's a cell-eat-cell world: autophagy and phagocytosis.
- Microdevices for Isolating Single Axons for the Study of Axonal Transport in Dopaminergic Neurons
- A Standardized Randomized 6-Month Aerobic Exercise-Training Down-regulated Pro-inflammatory Genes, but Up-regulated Anti-inflammatory, Neuron Survival and Axon Growth-Related Genes
- An Early Axonopathy in a hLRRK2(R1441G) Transgenic Model of Parkinson Disease
- Early and Sustained Activation of Autophagy in Degenerating Axons after Spinal Cord Injury
- Stimulation of Autophagy Prevents Amyloid-β Peptide-Induced Neuritic Degeneration in PC12 Cells
- Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy
- An evaluation of the links between microRNA, autophagy, and epilepsy
- Retrograde and Wallerian axonal degeneration occur synchronously after retinal ganglion cell axotomy.
- Modulating macroautophagy: a neuronal perspective
- Axonal degeneration as a therapeutic target in the CNS
- Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2
- The degeneration of dopaminergic synapses in Parkinson's disease: A selective animal model.
- NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases
- Activation of mTOR: a culprit of Alzheimer’s disease?
- Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons.
- Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson’s disease
- Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging.
- Neurotrophic Effects of Serum- and Glucocorticoid-Inducible Kinase (SGK) on Adult Murine Mesencephalic Dopamine Neurons
- Impaired autophagy in neurons following disinhibtion of mTOR and its contribution to epileptogenesis
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