Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits.
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Summary
Evidence is presented that macroautophagy is a significant pathway for lipid turnover, which is defective in TgCRND8 brain where lipids accumulate as membranous structures and lipid droplets within giant neuronal autolysosomes, and that autophagic-lysosomal dysfunction in T gCRND 8 brain impedes lysosomal turnover of lipids as well as proteins.
- Type
- dissertation
- Published
- 2014-12-01
- Cited by
- 111
- References
- 102
- Access
- Open access
- OpenAlex
- https://openalex.org/W25270989
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25996210
Keywords
Bioheat transfer, Heat transfer, Convective heat transfer, Ablation, Heat transfer coefficient
References
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Cited by
- Gene Expression and Alzheimer's Disease: Evaluation of Gene Expression Patterns in Brain and Blood for an Alzheimer's Disease Mouse Model
- The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease
- Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance
- Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors
- Autophagic flux and autophagosome morphogenesis require the participation of sphingolipids
- Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation.
- A role for lysosomal pH dysfunction in Alzheimer's disease and strategies for its restoration
- Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency
- Lysosomal cell death mechanisms in aging.
- The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases?
- Gypenoside XVII Enhances Lysosome Biogenesis and Autophagy Flux and Accelerates Autophagic Clearance of Amyloid-β through TFEB Activation
- Lysosomal storage disorders and neurodegenerative disease; related mechanisms of pathogenesis and identification of novel therapeutic targets
- Investigating the function of CLU in Alzheimer's Disease in in vitro and in vivo models
- Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation
- Disorders of lysosomal acidification - the emerging role of v-ATPase in aging and neurodegenerative disease
- p62 improves AD-like pathology by increasing autophagy
- The lysosomal storage disease continuum with ageing-related neurodegenerative disease.
- A Molecular Probe for the Detection of Polar Lipids in Live Cells
- Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats
- Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles
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