Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea.
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Summary
The results suggest that green tea flavonoids can modulate both MyD88- and TRIF-dependent signaling pathways of TLRs and subsequent inflammatory target gene expression.
- Type
- article
- Published
- 2006-09-28
- Cited by
- 178
- References
- 48
- OpenAlex
- https://openalex.org/W1989038593
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22240118
Keywords
TRIF, IRF3, TANK-binding kinase 1, TLR3, Signal transduction
References
- Specific Inhibition of MyD88-Independent Signaling Pathways of TLR3 and TLR4 by Resveratrol: Molecular Targets Are TBK1 and RIP1 in TRIF Complex1
- Toll-like receptors and innate immunity
- Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: mediation through both mitogen-activated protein kinase and NF-kappaB signaling pathways in macrophages.
- Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex1
- A Green Tea-Derived Polyphenol, Epigallocatechin-3-Gallate, Inhibits IκB Kinase Activation and IL-8 Gene Expression in Respiratory Epithelium
- Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells.
- The Extra Domain A of Fibronectin Activates Toll-like Receptor 4*
- Murine TOLL-like Receptor 4 Confers Lipopolysaccharide Responsiveness as Determined by Activation of NFκB and Expression of the Inducible Cyclooxygenase*
- Modulation of the UVA activation of haem oxygenase, collagenase and cyclooxygenase gene expression by epigallocatechin in human skin cells
- The role of MyD88 and TLR4 in the LPS‐mimetic activity of Taxol
- Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line.
- Toll-like receptors.
- The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
- Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea.
- RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.
- The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6.
- Inhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidation.
- Suppression of lipopolysaccharide-induced nuclear factor-κB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IκB kinase activity in macrophages
- Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways.
- Involvement of ERK and protein tyrosine phosphatase signaling pathways in EGCG-induced cyclooxygenase-2 expression in Raw 264.7 cells.
Cited by
- The Role of Catechins in Cellular Responses to Oxidative Stress
- Induction of innate immune responses by plant-derived procyanidins and polysaccharides
- IFN-α/β Induction by dsRNA and Toll-Like Receptors Shortens Allograft Survival Induced by Costimulation Blockade: A Dissertation
- Suppression of the Expression of Cyclooxygenase-2 Induced by Toll-like Receptor 2, 3, and 4 Agonists by 6-Shogaol
- The TRIF/TBK1/IRF-3 activation pathway is the primary inhibitory target of resveratrol, contributing to its broad-spectrum anti-inflammatory effects.
- TLR Activation Prevents Hematopoietic Chimerism Induced by Costimulation Blockade: A Dissertation
- Nutrigenomics and proteomics in health and disease : food factors and gene interactions
- NF-κ B Activation and Cyclooxygenase-2 Expression Induced by Toll-Like Receptor Agonists can be Suppressed by Isoliquiritigenin
- Toll-like Receptor 4 (TLR4) modulation by synthetic and natural compounds: an update
- West Nile Virus Envelope Protein Inhibits dsRNA-Induced Innate Immune Responses1
- Plant‐Based Modulation of Toll‐like Receptors: An Emerging Therapeutic Model
- Major tea catechin inhibits dendritic cell maturation in response to microbial stimulation
- Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade
- TRIF adaptor signaling is important in abdominal aortic aneurysm formation.
- TLR4 Signaling Inhibitory Pathway Induced by Green Tea Polyphenol Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor
- The Adjuvanticity of a Mannosylated Antigen Reveals TLR4 Functionality Essential for Subset Specialization and Functional Maturation of Mouse Dendritic Cells1
- Sesamin Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibition of TLR4 Signaling Pathways
- IκB kinase ɛ (IKKɛ): A therapeutic target in inflammation and cancer
- Garlic (Allium sativum) Extract Inhibits Lipopolysaccharide-Induced Toll-Like Receptor 4 Dimerization
- Ovalbumin Induces Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression
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