Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia

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Summary

An oncogenic KrasG12D-dependent upregulation of GM-CSF in mouse pancreatic ductal epithelial cells (PDEC) is demonstrated and a pathway that links oncogenic activation to the evasion of anti-tumor immunity is identified.

Type
article
Published
2012-06-12
Cited by
700
References
50
Access
Open access

Keywords

Stromal cell, Cancer research, Biology, Downregulation and upregulation, KRAS

References

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