Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
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Summary
An oncogenic KrasG12D-dependent upregulation of GM-CSF in mouse pancreatic ductal epithelial cells (PDEC) is demonstrated and a pathway that links oncogenic activation to the evasion of anti-tumor immunity is identified.
- Type
- article
- Published
- 2012-06-12
- Cited by
- 700
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W2031960993
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29414483
Keywords
Stromal cell, Cancer research, Biology, Downregulation and upregulation, KRAS
References
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- Hierarchy of immunosuppressive strength among myeloid‐derived suppressor cell subsets is determined by GM‐CSF
Cited by
- Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer
- RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
- Macrophages: Biology and Role in the Pathology of Diseases
- Pancreatic Inflammation and Carcinogenesis
- Chronic Traumatic Encephalopathy: The Neuropathological Legacy of Traumatic Brain Injury
- Control of CD8 T-cell Infiltration into Tumors by Vasculature and Microenvironment
- Stress Response Pathways in Cancer
- State of the art and future directions of pancreatic ductal adenocarcinoma therapy.
- Perspectives in the treatment of pancreatic adenocarcinoma.
- Induction of T cell immunity overcomes resistance to PD-1 and CTLA-4 blockade and improves survival in pancreatic cancer
- Immune cells in pancreatic cancer
- Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response
- Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer.
- The role of Mnk1 kinase in pancreas biology and exocrine diseases
- TLR9 ligation in pancreatic stellate cells promotes tumorigenesis
- Emerging cytokine networks in colorectal cancer
- The role of CD4[superscript +]T cells during adoptive and active-specific cancer immunotherapy
- Epigenetic and Immune Regulation of Colorectal Cancer Stem Cells
- Imaging and Therapy of Pancreatic Cancer with Phosphatidylserine-Targeted Nanovesicles
- TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis
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