Immune cells in pancreatic cancer
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Summary
Pancreatic tumors are rich in immune cell infiltrates that include CD4+ T-cell subsets encompassing both regulatory T cells and TH17 cells, and re-activation of antitumor immunity should be investigated for use in pancreatic cancer prevention and therapy.
- Type
- article
- Published
- 2014-06-01
- Cited by
- 3
- References
- 11
- Access
- Open access
- OpenAlex
- https://openalex.org/W1570357851
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34175055
Keywords
Pancreatic cancer, Immune system, Cancer research, Cancer, Medicine
References
- Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.
- Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice.
- Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
- Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
- Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia
- Interleukin 6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance
- Dynamics of the immune reaction to pancreatic cancer from inception to invasion.
- Tumor-derived granulocyte-macrophage colony stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
- Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
- CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in Mice
Cited by
- CD4+ T cells potently induce epithelial-mesenchymal-transition in premalignant and malignant pancreatic ductal epithelial cells–novel implications of CD4+ T cells in pancreatic cancer development
- The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives
- Interleukin-17 activates and synergizes with the notch signaling pathway in the progression of pancreatic ductal adenocarcinoma.
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