Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation.
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Summary
It is shown that tumors may be able to escape from immune detection by producing "unopposed" GM-CSF, thereby disrupting the balance of cytokines needed for the maturation of fully functional DC, and that CD11b/Gr-1 double-positive cells may function as "inhibitory" APC under the influence of GM- CSF alone.
- Type
- article
- Published
- 1999-05-15
- Cited by
- 452
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W1788753937
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9412722
Keywords
CD8, Immune system, Biology, Granulocyte macrophage colony-stimulating factor, Immunology
References
- Immunocompromised tumor-bearing mice show a selective loss of STAT5a/b expression in T and B lymphocytes.
- IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases.
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- Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
- Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen.
- Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory.
- Dendritic cells and the control of immunity
- Mechanisms of Tumor-Induced Immunosuppression: Evidence for Contact-Dependent T Cell Suppression by Monocytes
- Alkali hydrolysis of recombinant proteins allows for the rapid identification of class I MHC-restricted CTL epitopes.
- A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.
- Neutrophil Granulocyte–committed Cells Can Be Driven to Acquire Dendritic Cell Characteristics
- Enhanced Tumor Protection by Granulocyte-Macrophage Colony-Stimulating Factor Expression at the Site of an Allogeneic Vaccine
- Radiation and stress-induced apoptosis: a role for Fas/Fas ligand interactions.
- Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
- Developing recombinant and synthetic vaccines for the treatment of melanoma.
- Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.
- GM-CSF secretion in primary cultures of normal and cancerous human renal cells.
- The influence of granulocyte/macrophage colony‐stimulating factor on dendritic cell levels in mouse lymphoid organs
- Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells
Cited by
- Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen
- Relationship of vaccine efficacy to the kinetics of DC and T-cell responses induced by PLG-based cancer vaccines
- Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer
- Étude métabolique des cellules myéloïdes suppressives dans le contexte du phénomène d'immunosuppression
- Pancreatic Ductal Adenocarcinoma: A Review of Immunologic Aspects
- Rôles des cellules myéloïdes suppressives et des infiltrats immunitaires dans le cancer
- Immunosuppressive networks in the tumour environment and their effect in dendritic cells.
- Anti-tumor and pro-tumor interactions of human NK cells in cancer
- MANIPULATION OF REGULATORY MYELOID CELL DIFFERENTIATION AND FUNCTION AND ITS THERAPEUTIC IMPLICATIONS
- Immunomodulatory Therapy of Solid Tumors : With a Focus on Monoclonal Antibodies
- Myeloid-Derived Suppressor Cells: Critical Cells Driving Immune Suppression in the Tumor Microenvironment
- Effect of Yanghyeoljeseuptang (YHJST) Composition on Atopic Dermatitis NC/Nga Mice Induced by DNCB(dinitrochlorobenzene)
- Early Events Leading to the Host Protective Th2 Immune Response to an Intestinal Nematode Parasite
- Chemoattraction of femoral CD34+ progenitor cells by tumor-derived vascular endothelial cell growth factor
- Caractérisation moléculaire et fonctionnelle des lymphocytes T CD8+/CD103+ infiltrant les tumeurs pulmonaires humaines
- Metabolic regulation of hepatic immunopathology by myeloid-derived suppressor cells
- Effect of Gupoongjeseuptang (GPJST) on DNCB (dinitrochlorobenzene)-induced Atopic Dermatitis-like Model NC/Nga Mice
- The Role of Myeloid-Derived Suppressor Cells in the Immunotherapy of Breast Carcinomas
- Chronic Inflammation-Related HPV: A Driving Force Speeds Oropharyngeal Carcinogenesis
- The assessment of T-cell subsets in response to treatment in patients with breast or oesophageal cancer
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