TLR9 ligation in pancreatic stellate cells promotes tumorigenesis
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Summary
It is shown that TLR9 stimulation has a protumorigenic effect in pancreatic carcinoma by inducing pancreatic stellate cells to become fibrogenic and produce chemokines that stimulate epithelial cell proliferation.
- Type
- article
- Published
- 2015-10-26
- Cited by
- 164
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W1800750649
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13840854
Keywords
TLR9, Carcinogenesis, Tumor microenvironment, Cancer research, Hepatic stellate cell
References
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- Tumor Cell-derived MMP-3 Orchestrates Rac1b and Tissue Alterations that Promote Pancreatic Adenocarcinoma
- TLR7 promotes tumor progression, chemotherapy resistance, and poor clinical outcomes in non-small cell lung cancer.
Cited by
- Pancreatic cancer takes its Toll
- TCR-engineered T cells to treat tumors: Seeing but not touching?
- The Necrosome Promotes Pancreas Oncogenesis via CXCL1 and Mincle Induced Immune Suppression
- Toll-like receptor stimulation in cancer: A pro- and anti-tumor double-edged sword.
- Targeting tumor tolerance: A new hope for pancreatic cancer therapy?
- TLR9 re-expression in cancer cells extends the S-phase and stabilizes p16INK4a protein expression
- γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation
- Constitutive IRAK4 Activation Underlies Poor Prognosis and Chemoresistance In Pancreatic Ductal Adenocarcinoma
- Metabolite and microbiome interplay in cancer immunotherapy
- Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study
- Molecular Pathways: The Necrosome—A Target for Cancer Therapy
- High toll-like receptor (TLR) 9 expression is associated with better prognosis in surgically treated pancreatic cancer patients
- Galectin-1-driven upregulation of SDF-1 in pancreatic stellate cells promotes pancreatic cancer metastasis.
- Cancer Manipulation of Host Physiology– Lessons from Pancreatic Cancer
- Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer
- Dectin-1 Activation on Macrophages by Galectin-9 Promotes Pancreatic Carcinoma and Peritumoral Immune-Tolerance
- NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma
- Impact of viral and host DNA methylations on HPV16-related cervical cancer pathogenesis
- Pancreatic stellate cells: what's new?
- Oral microbial dysbiosis precedes development of pancreatic cancer
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