TLR9 ligation in pancreatic stellate cells promotes tumorigenesis

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Summary

It is shown that TLR9 stimulation has a protumorigenic effect in pancreatic carcinoma by inducing pancreatic stellate cells to become fibrogenic and produce chemokines that stimulate epithelial cell proliferation.

Type
article
Published
2015-10-26
Cited by
164
References
62
Access
Open access

Keywords

TLR9, Carcinogenesis, Tumor microenvironment, Cancer research, Hepatic stellate cell

References

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