The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
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Summary
It is found that the Rag proteins—a family of four related small guanosine triphosphatases (GTPases)—interact with mTORC1 in an amino acid–sensitive manner and are necessary for the activation of the m TORC1 pathway by amino acids.
- Type
- article
- Published
- 2008-06-13
- Cited by
- 2,819
- References
- 32
- OpenAlex
- https://openalex.org/W2025176940
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35690420
Keywords
mTORC1, GTPase, Cell biology, Biology, Amino acid
References
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- Molecular Mechanisms of Programmed Necrotic Death Initiated by Intrinsic Death Signals
- Phosphatidylinositol 3-kinase (PI3K): The Oncoprotein
- Association of aminoacyl-tRNA synthetases with cancer.
- Regulation of TOR by small GTPases
- Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects
- Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program.
- The role of amino acids in skeletal muscle adaptation to exercise.
- TORC1 Signaling Is Governed by Two Negative Regulators in Fission Yeast
- AKT-independent PI3-K signaling in cancer – emerging role for SGK3
- Targeting the Mammalian Target of Rapamycin (mTOR) in Cancer Therapy: Lessons from Past and Future Perspectives
- Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α*
- Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway*
- Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy
- The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.
- The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase
- Cystinosin is a Component of the Vacuolar H+-ATPase-Ragulator-Rag Complex Controlling Mammalian Target of Rapamycin Complex 1 Signaling.
- Erratum to: Amino acids and autophagy: their crosstalk, interplay and interlock
- PRL-3 activates mTORC1 in Cancer Progression
- Regulation of Eukaryotic Translation Initiation by Signal Transduction
- The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator*
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