The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase
Explore this paper's citation graph
Summary
Evidence is provided that mTOR regulates the opening and closing of the lysosomal channel responsible for MLIV through phosphorylation, which is essential for the development of mucolipidosis type IV.
- Type
- article
- Published
- 2015-07-20
- Cited by
- 70
- References
- 84
- Access
- Open access
- OpenAlex
- https://openalex.org/W26195823
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13310379
Keywords
Dictatorship, Ignorance, Humanities, Politics, Period (music)
References
- Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae.
- Phosphoproteomic Analysis of the Developing Mouse Brain*S
- The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
- Forskolin and derivatives as tools for studying the role of cAMP.
- Mucolipidosis IV: ocular, systemic, and ultrastructural findings.
- Mucolipidosis type IV: Abnormal transport of lipids to lysosomes
- Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications.
- Identification of the gene causing mucolipidosis type IV
- Two Di-Leucine Motifs Regulate Trafficking of Mucolipin-1 to Lysosomes
- Monitoring Autophagy in Lysosomal Storage Disorders
- How to Interpret LC3 Immunoblotting
- Phosphatidylcholine storage in mucolipidosis IV.
- The many faces of H89: a review.
- CHONDROCYTE AUTOPHAGY IS STIMULATED BY HIF-1 DEPENDENT AMPK ACTIVATION AND mTOR SUPPRESSION
- H89, an inhibitor of PKA and MSK, inhibits cyclic-AMP response element binding protein-mediated MAPK phosphatase-1 induction by lipopolysaccharide
- Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy
- Autophagy, a guardian against neurodegeneration
- Phospholipids accumulation in mucolipidosis IV cultured fibroblasts
- LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
- Drosophila S6 kinase: a regulator of cell size.
Cited by
- “TRP inflammation” relationship in cardiovascular system
- A Molecular Mechanism to Regulate Lysosome Motility for Lysosome Positioning and Tubulation
- Lysosomal Storage Diseases—Regulating Neurodegeneration
- Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression
- Suppression of the motor deficit in a mucolipidosis type IV mouse model by bone marrow transplantation.
- Multifaceted Roles of ALG-2 in Ca2+-Regulated Membrane Trafficking
- The lysosome: a crucial hub for AMPK and mTORC1 signalling.
- TRPML1: The Ca(2+)retaker of the lysosome.
- IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer
- Ion channels in the regulation of autophagy
- mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome
- A negative feedback regulation of MTORC1 activity by the lysosomal Ca2+ channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism
- Regulation of Lysosomal Adaptation to Nutrient Starvation by Lysosomal TRPML1 and PIKfyve
- Current concepts in the neuropathogenesis of mucolipidosis type IV
- Fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis IV
- TRPML1: Role In Autophagy And Potential Target To Treat Lysosomal Storage Disorders
- The protein interaction networks of mucolipins and two-pore channels
- Lysosomal Ion Channels as Decoders of Cellular Signals
- The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways
- A34 EFFECT OF AUTOPHAGY INDUCTION VIA TRPML1 ACTIVATION ON HEPATIC STEATOSIS
Related papers
No related papers recorded.