Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway*
Explore this paper's citation graph
Summary
Orexin activates the mTOR pathway in the mouse brain and multiple cell lines expressing OX1R or OX2R via calcium-stimulated lysosome v-ATPase pathway, suggesting that the m TORC1 pathway functions downstream of orexin/GPCR signaling, which plays a crucial role in many physiological and metabolic processes.
- Type
- article
- Published
- 2014-10-02
- Cited by
- 48
- References
- 69
- Access
- Open access
- OpenAlex
- https://openalex.org/W2124552207
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24910664
Keywords
Orexin, mTORC1, Cell biology, Biology, PI3K/AKT/mTOR pathway
References
- Orexin A-induced extracellular calcium influx in prefrontal cortex neurons involves L-type calcium channels
- Calcium influx: an intracellular message of the mitogenic action of insulin-like growth factor-I.
- Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
- Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice.
- The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias.
- Genetic and familial aspects of narcolepsy
- OX1 orexin receptors activate extracellular signal-regulated kinase in Chinese hamster ovary cells via multiple mechanisms: the role of Ca2+ influx in OX1 receptor signaling.
- Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling
- Different mechanisms are involved in intracellular calcium increase by insulin‐like growth factors 1 and 2 in articular chondrocytes: Voltage‐gated calcium channels, and/or phospholipase C coupled to a pertussis‐sensitive G‐protein
- Hypocretin deficiency in narcoleptic humans is associated with abdominal obesity.
- Neuroprotective Effect of Orexin-A Is Mediated by an Increase of Hypoxia-inducible Factor-1 Activity in Rat
- Activation of a metabolic gene regulatory network downstream of mTOR complex 1
- The Orexin OX1 Receptor Activates a Novel Ca2+ Influx Pathway Necessary for Coupling to Phospholipase C*
- Purification and Properties of a Cytosolic V1-ATPase*
- Epidermal Growth Factor-induced Vacuolar (H+)-ATPase Assembly
- An expanded Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1
- Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.
- Cytosolic Ca2+ Homeostasis Is a Constitutive Function of the V-ATPase in Saccharomyces cerevisiae *
- Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.
- Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex.
Cited by
- Cellular metabolism and lysosomal mTOR signaling
- Role of Ca2+ signaling in skeletal muscle hypertrophy and atrophy
- Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells
- Recent Insights into the Structure, Regulation and Function of the V-ATPases
- DNA Repair—A Double-Edged Sword in the Genomic Stability of Cancer Cells—The Case of Chronic Myeloid Leukemia
- Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling
- Calcium modulation of doxorubicin cytotoxicity in yeast and human cells
- Strategies of Functional Foods Promote Sleep in Human Being
- The Function of V-ATPases in Cancer.
- Molecular neurobiology of mTOR.
- Orexin/Hypocretin Signaling.
- Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease.
- RNA-seq expression profiling of rat MCAO model following reperfusion Orexin-A
- The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases
- Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis
- A pH probe inhibits senescence in mesenchymal stem cells
- [Multimodality of clinical effects of orexin].
- Orexin-A Stimulates Insulin Secretion Through the Activation of the OX1 Receptor and Mammalian Target of Rapamycin in Rat Insulinoma Cells
- Differential Roles of Each Orexin Receptor Signaling in Obesity
- Phytogenic feed- and water-additives improve feed efficiency in broilers via modulation of (an)orexigenic hypothalamic neuropeptide expression.
Related papers
- Orexin Receptor Antagonists: a Promising Approach to the Treatment of Insomnia
- Complete inhibition of mTORC1 cascade is required to suppress hepatocarcinogenesis induced by AKT and Ras co-expression
- Both Type 1 and Type 2 Receptors Transmit the Behavioral Effects of Orexin/Hypocretin
- Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?
- Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study.
- Role of the orexin (hypocretin) system in contextual fear conditioning in rats
- The transcriptome analysis of orexin neurons
- Orexin Receptor Antagonists
- Structure–Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT‐462206: a Potent, Brain‐Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist
- P.1.c.033 Effect of once-daily almorexant treatment for 6 weeks on the sleep-wake cycle of normal Wistar rats