A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
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Summary
The identification of a somatic mutation in human breast, colorectal and ovarian cancers that results in a glutamic acid to lysine substitution at amino acid 17 (E17K) in the lipid-binding pocket of AKT1 is reported.
- Type
- article
- Published
- 2007-07-26
- Cited by
- 1,323
- References
- 37
- OpenAlex
- https://openalex.org/W2018023891
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4302164
Keywords
Pleckstrin homology domain, AKT1, Protein kinase B, Allosteric regulation, Mutation
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Cited by
- Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting
- Infrequent occurrence of PIK3CA mutations in chronic lymphocytic leukemia
- Absence of oncogenic AKT1 E17K mutation in prostate, esophageal, laryngeal and urothelial carcinomas, hepatoblastomas, gastrointestinal stromal tumors and malignant meningiomas
- PI3K/Akt pathway mutations in retinoblastoma.
- Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer
- Regulation of Adipocyte Differentiation by Distinct Subcellular Pools of Protein Kinase B (PKB/Akt)*
- NGF‐Dependent Activation of TrkA Pathway: A Mechanism for the Neuroprotective Effect of Troxerutin in D‐Galactose‐Treated Mice
- From man to mouse and back again: advances in defining tumor AKTivities in vivo
- Contribution of PKB/AKT signaling to thyroid cancer.
- Resistance to HER2-directed antibodies and tyrosine kinase inhibitors
- Oncogenic mutations in extramammary Paget's disease and their clinical relevance
- MOZ increases p53 acetylation and premature senescence through its complex formation with PML
- Mutation frequency in 15 common cancer genes in high-risk head and neck squamous cell carcinoma
- AKT-independent PI3-K signaling in cancer – emerging role for SGK3
- Targeting the PI3-kinase/Akt/mTOR Signaling Pathway
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- PI3K mutations in breast cancer: prognostic and therapeutic implications
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- Critical Molecular Pathways in Cancer Stem Cells ofChronic Myeloid Leukemia: A Dissertation
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