The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
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Summary
Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin μ or κ enhancer frequently develop a fatal lymphoma within a few months of birth and constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation.
- Type
- article
- Published
- 1985-12-12
- Cited by
- 1,817
- References
- 53
- OpenAlex
- https://openalex.org/W1968075576
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4272140
Keywords
Lymphoma, Oncogene, Enhancer, Biology, Transgene
References
- Deletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expression.
- Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells
- Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain.
- Involvement of c‐myc in MuLV‐induced T cell lymphomas in mice: frequency and mechanisms of activation.
- Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.
- Erythroid‐specific expression of human beta‐globin genes in transgenic mice.
- The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes.
- Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.
- Transcripts from the Cellular Homologs of Retroviral Oncogenes: Distribution Among Chicken Tissues
- Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines
- Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.
- The immunoglobulin μ constant region gene is expressed in mouse thymocytes
- High expression of cloned immunoglobulin k gene in transgenic mice is restricted to B lymphocytes
- Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis
- Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
- Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes.
- The translocated c-myc oncogene of Raji Burkitt lymphoma cells is not expressed in human lymphoblastoid cells.
- A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene
- Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring.
- Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma
Cited by
- Regulation of Myc: Max complex formation and its potential role in cell proliferation.
- Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease
- c-myc oncogene copy number in squamous carcinoma of the head and neck.
- Survival factors and apoptosis.
- Hemopoietic lineage switch: v-raf oncogene converts Emu-myc transgenic B cells into macrophages.
- Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes.
- Transgenic mice as future tools in risk assessment.
- Myc family of cellular oncogenes
- Recessive genetic deregulation abrogates c-myc suppression by interferon and is implicated in oncogenesis
- Oncogenes, viruses, or rheumogenes?
- Context dependent transactivation domains activate the immunoglobulin mu heavy chain gene enhancer.
- Chemical carcinogenesis: from animal models to molecular models in one decade.
- Telomerase activation: one step on the road to cancer?
- Manipulating the germline: its impact on the study of carcinogenesis.
- Lymphoma‐ and leukemia‐associated chromosomal translocations in healthy individuals
- Alterations in the apoptotic machinery and their potential role in anticancer drug resistance
- Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia.
- Transgenic mice as an in vivo model of lymphomagenesis.
- Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease.
- B cell development and its deregulation to transformed states at the pre-B cell receptor-expressing pre-BII cell stage.
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