Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells.
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Summary
It is demonstrated that thymoproteasome-dependent self-peptide production is required for the development of an immunocompetent repertoire of CD8+ T cells.
- Type
- article
- Published
- 2010-01-29
- Cited by
- 225
- References
- 80
- Access
- Open access
- OpenAlex
- https://openalex.org/W2011833868
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33625456
Keywords
Biology, Repertoire, CD8, Cytotoxic T cell, T-cell receptor
References
- The MHC reactivity of the T cell repertoire prior to positive and negative selection.
- Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.
- Cathepsin L Regulates CD4+ T Cell Selection Independently of Its Effect on Invariant Chain
- Modest cortex and promiscuous medulla for thymic repertoire formation.
- Development of T-lymphocytes in mouse fetal thymus organ culture.
- Peripheral T Lymphocytes Recirculating Back into the Thymus Can Mediate Thymocyte Positive Selection
- Noninvasive Intravital Imaging of Thymocyte Dynamics in Medaka1
- An In Vivo Cytotoxicity Threshold for Influenza A Virus-Specific Effector and Memory CD8+ T Cells1
- PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins.
- Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
- Cell death and immunity: Negative selection — clearing out the bad apples from the T-cell repertoire
- T cell receptor antagonist peptides induce positive selection.
- CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens
- Making sense of mass destruction: quantitating MHC class I antigen presentation
- The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery.
- Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
- CD4+ T cells are ineffective in clearing a pulmonary infection with influenza type A virus in the absence of B cells.
- Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors.
- Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
- Fibroblasts can induce thymocyte positive selection in vivo.
Cited by
- Effects of RANKL on the thymic medulla
- Positive-selection-inducing self-peptides displayed by cortical thymic epithelial cells.
- PSMB11 Orchestrates the Development of CD4 and CD8 Thymocytes via Regulation of Gene Expression in Cortical Thymic Epithelial Cells
- Assembly and function of the proteasome.
- Self-peptides in TCR repertoire selection and peripheral T cell function.
- Thymic Development and Selection of T Lymphocytes
- The Ubiquitin-like modifier FAT10 in tolerance induction
- Sex hormones have pervasive effects on thymic epithelial cells
- 200 Million Thymocytes and I: A Beginner's Survival Guide to T Cell Development.
- Cancer and aging: a multidisciplinary medicinal chemistry approach on relevant biological targets such as proteasome, sirtuins and interleukin 6
- Thymic selection and lineage commitment of CD4(+)Foxp3(+) regulatory T lymphocytes.
- Functional Development of the T Cell Receptor for Antigen
- Genome duplication and T cell immunity.
- Study of the immunological phenotype of metastases obtained from mice receiving different immonotherapy protocols
- Target validation of UK-101 and functional studies of beta1i
- Development and function of cortical thymic epithelial cells.
- Monocyte chemoattractant protein 1 (MCP‐1/CCL2) contributes to thymus atrophy in acute myeloid leukemia
- Production d'un peptide antigénique par l'insulin-degrading enzyme
- T‐cell receptor affinity in thymic development
- Positive selection of self‐antigen‐specific CD8+ T cells by hematopoietic cells
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