Functional Development of the T Cell Receptor for Antigen
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Summary
Recent findings relating to T cell antigen recognition are discussed and how this leads to the thymic development of foreign-antigen-responsive αβT cells are discussed.
- Type
- article
- Published
- 2010-01-01
- Cited by
- 15
- References
- 169
- Access
- Open access
- OpenAlex
- https://openalex.org/W1511147168
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25481512
Keywords
T-cell receptor, Antigen, Major histocompatibility complex, T cell, Biology
References
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- The variable immunological self: Genetic variation and nongenetic noise in Aire-regulated transcription
- An endogenous peptide positively selects and augments peripheral CD4+ T cell activation and survival
- Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity.
- Germline-encoded amino acids in the αβ T cell receptor control thymic selection
- Structurally similar TCRs differ in their efficiency of positive selection.
- Cutting edge: negative selection of immature thymocytes by a few peptide-MHC complexes: differential sensitivity of immature and mature T cells.
- SIT and TRIM Determine T Cell Fate in the Thymus1
- The Lymphotoxin Pathway Regulates Aire-Independent Expression of Ectopic Genes and Chemokines in Thymic Stromal Cells1
- Dissecting microRNA-mediated gene regulation and function in T-cell development.
- T cell receptor junctional regions and the MHC molecule affect the recognition of antigenic peptides by T cell clones.
- Positive Selection Is Limited by Available Peptide-Dependent MHC Conformations1
- The impact of negative selection on thymocyte migration in the medulla
- Three-dimensional segregation of supramolecular activation clusters in T cells
- The role of polymorphic amino acids of the MHC molecule in the selection of the T cell repertoire.
- Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
- Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
- Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103).
Cited by
- Self-peptides in TCR repertoire selection and peripheral T cell function.
- Thymic Development and Selection of T Lymphocytes
- Diversity index of mucosal resident T lymphocyte repertoire predicts clinical prognosis in gastric cancer
- A stochastic T cell response criterion
- Safety analysis of TCR gene-modified T cells
- Open Peer Review
- Engineering approaches for regeneration of T lymphopoiesis
- Recent advances in T-cell engineering for use in immunotherapy
- Optimization of strategies for anti-cancer vaccines
- Characterization of Distinct T Cell Receptor Repertoires in Tumor and Distant Non-tumor Tissues from Lung Cancer Patients
- Implications of T cell receptor biology on the development of new T cell therapies for cancer.
- TCR repertoire characteristics predict clinical response to adoptive CTL therapy against nasopharyngeal carcinoma
- Epigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity
- Tumor Derived Extracellular Vesicles Modulate Gene Expression in T Cells.
- Characteristics of profiling the peripheral blood T-cell receptor β-chain repertoire in gastric cancer
- Investigating the Chronic Inflammatory Response to Stroke: The Role of Glial Scar Astrocytes and B-Lymphocytes
- Characteristics of pro ling the peripheral blood T- cell receptor β-chain repertoire in gastric cancer
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