Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide
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Summary
A system is described which detects simply engagement of the T CR by MHC/peptide complexes rather than the functional outcome of such interactions, suggesting that only a few peptides are able to prevent the TCR from contacting the MHC molecule.
- Type
- article
- Published
- 1997-04-01
- Cited by
- 9
- References
- 45
- OpenAlex
- https://openalex.org/W2011835836
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22750817
Keywords
T-cell receptor, Major histocompatibility complex, Biology, MHC restriction, Peptide
References
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- T-cell-receptor affinity and thymocyte positive selection
- A human‐human hybridoma system based on a fast‐growing mutant of the ARH‐77 plasma cell leukemia‐derived line
- The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase
- Positive and negative thymocyte selection induced by different concentrations of a single peptide.
- Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor
- Are MHC-bound peptides a nuisance for positive selection?
Cited by
- Flexibility in MHC and TCR Recognition: Degenerate Specificity at the T Cell Level in the Recognition of Promiscuous Th Epitopes Exhibiting No Primary Sequence Homology
- T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics.
- Axioms of mathe- matical immunology
- Autoantigen-independent deletion of diabetogenic CD4+ thymocytes by protective MHC class II molecules.
- Classical and Nonclassical Class I Major Histocompatibility Complex Molecules Exhibit Subtle Conformational Differences That Affect Binding to CD8αα*
- Killer Cell Immunoglobulin Receptors and T Cell Receptors Bind Peptide-Major Histocompatibility Complex Class I with Distinct Thermodynamic and Kinetic Properties*
- Effect of epitope variant co-delivery on the depth of CD8 T cell responses induced by HIV-1 conserved mosaic vaccines
- Exhibiting No Primary Sequence Homology the Recognition of Promiscuous Th Epitopes Degenerate Specificity at the T Cell Level in Flexibility in MHC and TCR Recognition:
- Protective MHC Class II Molecules Thymocytes by + Diabetogenic CD 4 Autoantigen-Independent Deletion of Bou and
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