T cell receptor antagonist peptides induce positive selection.
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Summary
Results show that the process of positive selection is exquisitely peptide specific and sensitive to extremely low ligand density and support the notion that low efficacy ligands mediate positive selection.
- Type
- article
- Published
- 1994-01-14
- Cited by
- 3,236
- References
- 40
- OpenAlex
- https://openalex.org/W1959677146
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31908126
Keywords
Biology, T-cell receptor, Negative selection, Peptide, CD8
References
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- Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition.
- β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells
- Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.
- Role of self-peptides in positively selecting the T-cell repertoire
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- A unified model for T cell antigen recognition and thymic selection of the T cell repertoire.
- Mutations in the major histocompatibility complex class I antigen‐presenting groove affect both negative and positive selection of T cells
- The level of CD8 expression can determine the outcome of thymic selection.
- The role of beta 2-microglobulin in peptide binding by class I molecules.
- Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I‐bound determinant
- Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells
- T cell receptor alpha-chain pairing determines the specificity of residue 262 within the Kb-restricted, ovalbumin257-264 determinant.
- Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.
- Activation events during thymic selection
- Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.
- Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
- Phenotypic and functional stages in the intrathymic development of alpha beta T cells.
- Engineered secreted T-cell receptor alpha beta heterodimers.
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- Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis.
- Partial T cell signaling: Altered phospho-ζ and lack of zap70 recruitment in APL-induced T cell anergy
- CD3‐induced apoptosis of CD4+CD8+ thymocytes in the absence of clonotypic T cell antigen receptor
- Reactivity and Specificity of CD8+ T Cells in Mice with Defects in the MHC Class I Antigen‐Presenting Pathway
- Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.
- The MHC reactivity of the T cell repertoire prior to positive and negative selection.
- Tolerance to p53 by A2.1-restricted Cytotoxic T Lymphocytes
- Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice.
- Antigen-specific inhibition of CD4+ T-cell responses to β-lactoglobulin by its single amino acid-substituted mutant form through T-cell receptor antagonism
- Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire.
- BAC-VAC, a novel generation of (DNA) vaccines: A bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1.
- Regulation of lineage commitment distinct from positive selection.
- Repeated Administration of Cytosine-Phosphorothiolated Guanine-Containing Oligonucleotides Together with Peptide/Protein Immunization Results in Enhanced CTL Responses with Anti-Tumor Activity1
- Thymus organ cultures and T‐cell receptor repertoire development
- LIGAND DENSITY DETERMINES THE EFFICIENCY OF NEGATIVE SELECTION IN THE THYMUS1
- Signaling Alterations in Activation-Induced Nonresponsive CD8 T Cells1
- Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells
- CD6: expression during development, apoptosis and selection of human and mouse thymocytes.
- Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin.
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