IFNα activates dormant haematopoietic stem cells in vivo
Explore this paper's citation graph
Summary
It is shown that in response to treatment of mice with interferon-α (IFNα), HSCs efficiently exit G0 and enter an active cell cycle, raising the possibility for new applications of type I interferons to target cancer stem cells.
- Type
- article
- Published
- 2009-04-16
- Cited by
- 1,235
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2011059916
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205216119
Keywords
Stem cell, Haematopoiesis, Biology, Cancer research, Cell biology
References
- Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment.
- First-Line management of CML: a state of the art review.
- 5-Fluorouracil spares hemopoietic stem cells responsible for long-term repopulation.
- Optimal initial therapy for patients with newly diagnosed chronic myeloid leukemia in chronic phase
- Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice.
- Innate recognition of viruses.
- Therapeutic targets in chronic myeloid leukaemia
- Functional role of type I and type II interferons in antiviral defense.
- Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years.
- Dormant and Self‐Renewing Hematopoietic Stem Cells and Their Niches
- The role of interferon-alpha in the treatment of chronic myeloid leukemia.
- Concise Review: Stem Cell Antigen‐1: Expression, Function, and Enigma
- Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
- Interferons at age 50: past, current and future impact on biomedicine
- Mechanisms of Disease: cancer stem cells—targeting the evil twin
- Inducible gene targeting in mice
- Bone-marrow haematopoietic-stem-cell niches
- Complex modulation of cell type-specific signaling in response to type I interferons.
- Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity.
- c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation.
Cited by
- Stemming out of a new PML era?
- Molecular pathology of tumor‐initiating cells: Lessons from Philadelphia chromosome‐positive leukemia
- Expansion of functionally defined mouse hematopoietic stem and progenitor cells by a short isoform of RUNX1/AML1.
- Clinical Trials in Chronic Myeloid Leukemia
- Altered Immunity and Dendritic Cell Activity in the Periphery of Mice after Long-Term Engraftment with Bone Marrow from Ultraviolet-Irradiated Mice
- Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
- Myocardial infarction activates CCR2+ hematopoietic stem and progenitor cells
- Stroma-Derived Connective Tissue Growth Factor Maintains Cell Cycle Progression and Repopulation Activity of Hematopoietic Stem Cells In Vitro
- Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment.
- Mobilized Peripheral Blood versus Cord Blood: Insight into the Distinct Role of Proinflammatory Cytokines on Survival, Clonogenic Ability, and Migration of CD34+ Cells
- The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.
- IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock
- Role of the Notch1 TAD in embryonic development and hematopoiesis
- JAK-STAT signaling in stem cells.
- Type I Interferons and the Development of Impaired Vascular Function and Repair in Human and Murine Lupus
- The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation
- Cell Fusion, Drug Resistance and Recurrence CSCs.
- Lineage relationship analysis of lymphoid progenitor subsets in the bone marrow of naïve mice and during inflammation
- HIV-1 Infection of Hematopoietic Progenitor Cells.
- Hematopoietic stem cells: interplay with immunity.
Related papers
- Participation of humoral factors in the regulation of hemopoiesis in cytostatic myelodepression
- Clonal origin of haematopoietic colonies in the postnatal mouse liver
- Estrogen increases haematopoietic stem cell self-renewal in females and during pregnancy
- From haematopoietic stem cells to complex differentiation landscapes
- Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: evidence for a pre-CFU-S cell?
- Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function
- Stem cells: Sex specificity in the blood
- Bloodlines of haematopoietic stem cell research in Japan
- Autophagy maintains the metabolism and function of young and old (hematopoietic) stem cells
- Lineage Decision-Making within Normal Haematopoietic and Leukemic Stem Cells