Complex modulation of cell type-specific signaling in response to type I interferons.
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Summary
The type I interferons are pleiotropic cytokines that regulate many different cellular functions in different types of cells, by activating different specific signals and patterns of gene expression.
- Type
- review
- Published
- 2006-09-01
- Cited by
- 561
- References
- 122
- Access
- Open access
- OpenAlex
- https://openalex.org/W2040653543
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45114476
Keywords
Biology, Janus kinase, stat, Cell biology, Phosphorylation
References
- Differential effects of interferon alpha-2b and beta on the signaling pathways in human liver cancer cells
- Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN‐alpha and IFN‐beta.
- Stat-1 Is Not Essential for Inhibition of B Lymphopoiesis by Type I IFNs1
- Differential Use of the βL Subunit of the Type I Interferon (IFN) Receptor Determines Signaling Specificity for IFNα2 and IFNβ*
- The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors.
- IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells.
- Induction of β-R1/I-TAC by Interferon-β Requires Catalytically Active TYK2*
- Stat4 Is Expressed in Activated Peripheral Blood Monocytes, Dendritic Cells, and Macrophages at Sites of Th1-Mediated Inflammation1
- Interferon alpha induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells.
- Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation1
- Down-Modulation of Responses to Type I IFN Upon T Cell Activation1
- IFN-gamma priming up-regulates IFN-stimulated gene factor 3 (ISGF3) components, augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs.
- IFN-Stimulated Gene 15 Is Synergistically Activated Through Interactions Between the Myelocyte/Lymphocyte-Specific Transcription Factors, PU.1, IFN Regulatory Factor-8/IFN Consensus Sequence Binding Protein, and IFN Regulatory Factor-4: Characterization of a New Subtype of IFN-Stimulated Response El
- Different Relative Activities of Human Cell-Derived Interferon-α Subtypes: IFN-α8 Has Very High Antiviral Potency
- Stimulation of Primary Human Endothelial Cell Proliferation by IFN1
- Stat1-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand and the cell-surface death signaling pathway by interferon beta in human cancer cells.
- Tyrosine phosphorylation of the alpha and beta subunits of the type I interferon receptor. Interferon-beta selectively induces tyrosine phosphorylation of an alpha subunit-associated protein.
- Gene Regulation and Clinical Roles for Interferons in Neoplastic Diseases.
- CCAAT/Enhancer Binding Proteins and Interferon Signaling Pathways
- A Negative Regulatory Region in the Intracellular Domain of the Human Interferon-α Receptor*
Cited by
- Cholesterol manipulation by West Nile virus perturbs the cellular immune response.
- Adenovirus Induction of IRF3 Occurs through a Binary Trigger Targeting Jun N-Terminal Kinase and TBK1 Kinase Cascades and Type I Interferon Autocrine Signaling
- Identifying Molecular Markers for Chemosensitivity to Gemcitabine in Pancreatic Cancer: Increased Expression of Interferon-Stimulated Gene 15 kd Is Associated With Intrinsic Chemoresistance
- The Type I Interferon-α Mediates a More Severe Neurological Disease in the Absence of the Canonical Signaling Molecule Interferon Regulatory Factor 9
- Type I interferons in systemic autoimmunity
- Oncolytic Sindbis virus targets tumors defective in the interferon response and induces significant bystander antitumor immunity in vivo.
- Identification and utility of innate immune system evasion mechanisms of ASFV.
- Type I interferon in neurological disease-the devil from within.
- Systems biology unravels interferon responses to respiratory virus infections.
- A pathogenic IFNα, BLyS and IL-17 axis in Systemic Lupus Erythematosus patients
- 6‐Hydroxy‐3‐O‐methyl‐kaempferol 6‐O‐glucopyranoside potentiates the anti‐proliferative effect of interferon &agr;/&bgr; by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells
- The role of inflammation in kidney cancer.
- Place des cellules dendritiques plasmocytoïdes dans l'immunité innée anti-tumorale : de leur activation par des ligands de TLR à leur fonctionnalité en contexte de mélanome
- T cell Regulatory Plasmacytoid Dendritic Cells Expressing Indoleamine 2,3 Dioxygenase
- Structural basis of viral RNA recognition by RIG-I-like receptors
- Hepatitis C virus: standard-of-care treatment.
- Improving lentiviral vector-mediated gene transfer by understanding cellular barriers
- Conceptus-uterus interactions in pigs: endometrial gene expression in response to estrogens and interferons from conceptuses.
- Negative regulation of host innate antiviral signaling
- Hierarchical Feedback Modules and Reaction Hubs in Cell Signaling Networks
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