Concise Review: Stem Cell Antigen‐1: Expression, Function, and Enigma
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Summary
A review of the plethora of recent findings utilizing Sca‐1 as a parenchymal stem cell marker and detailing its functional role in stem and progenitor cells and also attempts to explain the lingering mysteries surrounding its biochemical function and human ortholog.
- Type
- review
- Published
- 2007-06-01
- Cited by
- 421
- References
- 123
- Access
- Open access
- OpenAlex
- https://openalex.org/W2024174149
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6514438
Keywords
Biology, Stem cell, Progenitor cell, Cancer stem cell, Haematopoiesis
References
- Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection
- The Role of the Sca‐1+/CD31− Cardiac Progenitor Cell Population in Postinfarction Left Ventricular Remodeling
- Isolation of a murine Ly‐6 cDNA reveals a new multigene family.
- Mesenchymal Stem Cells
- Functional and molecular characterisation of mammary side population cells
- Decline in bone marrow proliferative capacity as a function of age.
- Down-regulation of IL-2 production by activation of T cells through Ly-6A/E.
- Stimulation of T cells via the TAP molecule, a member in a family of activating proteins encoded in the Ly-6 locus.
- Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon
- Isolation, expression, and sequence of the TAP/Ly-6A.2 chromosomal gene.
- Biochemical characterization of the murine activated lymphocyte alloantigen Ly-6E.1 controlled by the Ly-6 locus.
- Lipid rafts and signal transduction
- Two monoclonal antibodies identify thymic-repopulating cells in mouse bone marrow.
- Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
- In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells.
- Characterization of Ly-6M, a novel member of the Ly-6 family of hematopoietic proteins.
- Regulated expression of Ly-6A.2 is important for T cell development.
- A cell surface antigenic determinant present on mouse plasmacytes and only about half of mouse thymocytes.
- Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a zeta-independent pathway.
- Muscle-derived CD45−Sca-1+c-kit− progenitor cells give rise to skeletal muscle myotubes in vitro
Cited by
- Does the tongue eloquently address the question of cardiac regeneration?
- Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia
- Heterogeneity of tumor endothelial cells: comparison between tumor endothelial cells isolated from high- and low-metastatic tumors.
- Contribution of a Major Quantitative Trait Locus to Mouse Adenovirus Type 1 Encephalitis and Mortality
- Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice.
- Mechanotransduction in cardiac stem cells : role of YAP/TAZ in the cellular response to the microenvironment
- Study of the role of Wnt pathway in a murine model of T-ALL
- Lineage-related and particle size-dependent cytotoxicity of chitosan nanoparticles on mouse bone marrow-derived hematopoietic stem and progenitor cells.
- Negative Regulation of TGFβ Signaling by Stem Cell Antigen-1 Protects against Ischemic Acute Kidney Injury
- ISOLATION AND CHARACTERIZATION OF MULTIPOTENT LUNG STEM CELLS FROM p53 MUTANT MICE MODELS
- Form and function: how estrogen and progesterone regulate the mammary epithelial hierarchy
- Sca-1+ Cardiac Progenitor Cells and Heart-Making: A Critical Synopsis
- Biomodification of PCL Scaffolds with Matrigel, HA, and SR1 Enhances De Novo Ectopic Bone Marrow Formation Induced by rhBMP-2
- THE ROLE OF STEM CELL ANTIGEN-1(Sca-1) IN MUSCLE AGING
- Multipotent stem cells of the heart—do they have therapeutic promise?
- ROLE OF STAT3 IN KERATINOCYTE STEM CELLS DURING SKIN TUMORIGENESIS
- Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence
- Pleiotrophin and its Role in Regulating Haemopoietic Stem Cell Regeneration
- Amplified luminal progenitors in prostates of prolactin-transgenic mice
- Hedgehog and Resident Vascular Stem Cell Fate
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