Immortalization and transformation of human cells.
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Summary
This review summarizes recent advances in understanding of molecular mechanisms that contribute to human cell immortalization and transformation and implicates cellular immortalization as a prerequisite for cell transformation.
- Type
- article
- Published
- 2002-06-01
- Cited by
- 26
- References
- 109
- Access
- Open access
- OpenAlex
- https://openalex.org/W205399872
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:260424867
Keywords
Cell biology, Cell growth, Biology, Transformation (genetics), Cell
References
- Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
- Absence of cancer–associated changes in human fibroblasts immortalized with telomerase
- Mortality and immortality at the cellular level. A review.
- The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
- Inhibition of telomerase limits the growth of human cancer cells
- A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.
- The illusion of cell immortality
- Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology
- Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
- Creation of human tumour cells with defined genetic elements
- The age of cancer
- A genetically tractable model of human glioma formation.
- Telomere maintenance by recombination in human cells
- Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
- Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
- Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
- Telomere elongation in immortal human cells without detectable telomerase activity.
- Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
- Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
- The Stability of Broken Ends of Chromosomes in Zea Mays.
Cited by
- Post-Transcriptional Control of Human Cellular Senescence: A Dissertation
- Gene Encoding Chitinase 3-Like 1 Protein (CHI3L1) is a Putative Oncogene
- Genetic and environmental factors influencing human diseases with telomere dysfunction.
- Generation and Characterization of Non-Small-Cell Lung Cancer Cell Lines and Clones for Use in the Study of Immunotherapy
- An RNA-seq-based Gene Expression Profiling of Radiation-induced Tumorigenic Mammary Epithelial Cells
- Hematopoietic Immortalizing Function of the NKL-Subclass Homeobox Gene TLX1
- Development and Characterization of Salivary Adenoid Cystic Carcinoma Cell Line
- Primary and immortalised human pancreatic islet endothelial cells: phenotypic and immunological characterisation
- Immortalization and functional characterization of rat arachnoid cell lines.
- The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium.
- THYMOQUINONE: THE EVALUATION OF ITS CYTOTOXIC POTENTIAL, EFFECTS ON P53 STATUS AND THE CELL CYCLE IN VARIOUS CANCER CELL LINES
- Epigenetic profiling of bronchial epithelial cells : DNA methylation
- Identification of a novel Rb-regulated gene associated with the cell cycle.
- Establishment and characterization of three immortal bovine muscular epithelial cell lines.
- Myogenic differentiation of p53- and Rb-deficient immortalized and transformed bovine fibroblasts in response to MyoD.
- A comprehensive review of metal‐induced cellular transformation studies
- Identification of a Gene Encoding Slow Skeletal Muscle Troponin T as a Novel Marker for Immortalization of Retinal Pigment Epithelial Cells
- The impact of sex and sex hormones on cell function
- Molecular signatures linked to stemness and tumorigenesis in tumorspheres from in vitro transformed cells
- Mechanisms of human papillomavirus and host gene transcriptional deregulation in cervical carcinogenesis
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